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On interaction between genetic factors and environmental factors.

Research Project

Project/Area Number 09670367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionTokyo Kasei University

Principal Investigator

HIGURASHI Makoto  Tokyo Kasei University, Division of Child Health Professor, 家政学部, 教授 (00010223)

Co-Investigator(Kenkyū-buntansha) ODA Masaaki  University of Tokyo, Department of Developmental Medicine Instructor, 医学部, 助手 (20160872)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsBlue Light / Newborn / Down Syndrome / Sister chromatid exchange / 百日咳菌 / 高発がん性 / 老化 / 免疫異常 / 退行
Research Abstract

This study determines whether irradiation by blue or green light has an adverse effect on the DNA of Down syndrome (DS) cells by examining the sister chromatid exchanges (SCE) frequency of peripheral lymphocytes obtained from five neonates with DS and five karyotypically normal neonates (control). Lymphocytes in Go of the cell cycle were irradiated with blue or green fluorescent light for 1, 2, 4 or 6 h, and then cultured using a conventional method. Our results revealed that the induction of SCEs per cell in both groups increased in a dose-dependent manner, although more SCEs were respectively induced by the blue light. In addition, after 6h of blue light irradiation, the net-induced SCEs in the DS groups were higher than those in the control groups.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] N.Kamatani et al.: "Down syndrome with coexistent gout ; report of six patients and possible reasons for scarcity of descriptions of this association." Ann.Rheum.Dis.55. 649-650 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 谷口和彦 他: "ダウン症児の環軸椎不安定症におけるT signの意義" 日本小児整形外科雑誌. 6. 266-270 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tezuka et al.: "Effects of compression stockings on blood pressure and its orthostatic change in female subjects." Pathophysiology. 4. 81-86 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 斎藤信太郎 他: "モザイク型20番環状染色体症の1例" 臨床脳波. 39. 131-138 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Oda et al.: "Effects of A-protomer and B-oligomer of pertussis toxin on murine immune response." Proc.Amer Soc.Microbiol.83-84 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 島田三恵子 他: "NICU入院児の睡眠覚醒リズムの発達" 小児保健研究. 57. 569-575 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Kamatani et al.: "Down syndrome with coexistent gout ; report of six patients and possible reasons for scarcity of descriptions of this association." Ann.Rheum. Dis.55. 649-650 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Taniguchi et al.: "Significance of the T sign suggest-ing atlanto-axial instability in chil-dren with Down syndrome." J.Pediat. Ortho.6. 266-270 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tezuka et al.: "Effects of compression stockings of blood pressure and its orthostatic change in fe-male subjects." Pathophysiology. 4. 81-86 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Saito et al.: "A case of ring (20) chromosomal mosicism." Clin.EEG.39. 131-138 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Oda et al.: "Effects of A-protomer and B-oligomer of pertussis toxin on murine immune re-sponse." Proc.Amer.Soc.Microbiol. 83-84 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Shimada et al.: "Development of sleep-wake rhythm in infants in NICU." J.Child Health. 57. 569-575 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Higurashi et al.: "Problems on care of the chidren with Down syndrome." (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Kamatani et al.: "Down syndrome with coexistent gout; report of six patients and possible reasons for scarcity of descriptions of this association." Ann.Rheum.Dis.55. 649-650 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 谷口 和彦 他: "ダウン症児の環軸椎不安定症におけるT signの意義" 日本小児整形外科雑誌. 6. 266-270 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Tezuka et al.: "Effects of compression stockings on blood pressure and its orthostatic change in female subjects." Pathophysiology. 4. 81-86 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 斎藤 信太郎 他: "モザイク型20番環状染色体症の1例" 臨床脳波. 39. 131-138 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Oda et al.: "Effects of A-protomer and B-oligomer of pertussis toxin on murine immune response." Proc.Amer Soc.Microbiol.83-84 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 島田 三恵子 他: "NICU入院児の睡眠覚醒リズムの発達" 小児保健研究. 57. 569-575 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kamatani,N.: "Down syndrome with coexistent gout" Ann.Rheum.Dis.55. 649-650 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fang-yang Wu.: "SCE in the peripheral lymphocytes of newborns with Down syndrome after in vitro exposure to blue or green light" Mutation Research. 367. 261-264 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 谷口和彦: "ダウン症児の環軸椎不安定症におけるT signの意義" 日小整会誌. 6. 266-270 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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