| Project/Area Number |
09670369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KONO Koichi Faculty of Medicine, Osaka Medical College, Professor, 医学部, 教授 (30111016)
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| Co-Investigator(Kenkyū-buntansha) |
ORITA Yukio Faculty of Medicine, Osaka Medical College, Lecturer, 医学部, 講師 (80247840)
WATANABE Misuzu Faculty of Medicine, Osaka Medical College, Lecturer, 医学部, 講師 (30084924)
DOTE Tomotaro Faculty of Medicine, Osaka Medical College, Lecturer, 医学部, 講師 (10257868)
USUDA Kan Faculty of Medicine, Osaka Medical College, Assistant, 医学部, 助手 (80298752)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | fluoride / exposure / renal failure / aging / 持続暴露 / 腎毒性 / 腎機能障害 / 近位尿細管 |
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| Research Abstract |
Several characteristics of the aging process related to real function and fluoride metabolism were investigated. A cross-sectional analysis of 1088 healthy subjects by 10-year age groups showed a progressive linear decline in car clearance (CCr) and fluoride clearance (CF).
The results suggest that renal fluoride clearance decreased not only with the evidence of kidney disease but also with advancing age. For the health care of workers exposed to fluoride and of populations living in fluoride polluted areas, age may be an important factor to be considered.
An excess of sodium fluoride (135mg F/kg body weight) was given in a single oral dose to male Wistar rats. Effects were investigated of fluoride-induced acute kidney intoxication on the time-dependent variations of urine volume. Also, of urinary fluoride ion (FィイD1-ィエD1), α-glutathione-S-transferase (α-GST), N-acetyl-β-D-glucosaminidase (NAG), and creatinine (CR) concentrations. Fluoride administration strongly affects these urinary biochemical indices.
The continuous high F exposure would cause severe nophrotoxicity in both glomeruli and tubule in early stage. In early stage of renal damages, GST would be a more sensitive nephrotoxic indicator of acute proximal tubular injuries than NAG in our study. Because F elimination is mainly dependent on kidney function, the accumulation of F would cause acute renal failure still more. The sensitive marker would be necessary for early diagnosis of F positioning in addition to the biological monitoring using urinary F concentration.
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