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Epidemiological and molecular biological study of familial factors in occurrence of children's leukemia

Research Project

Project/Area Number 09670380
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKyorin University (2000)
The University of Tokyo (1997-1999)

Principal Investigator

BESSHO Fumio  Kyorin University, Department of Pediatrics, Professor, 医学部, 教授 (40010285)

Co-Investigator(Kenkyū-buntansha) TANIMURA Masako  National Children's Medical Research Center, Department of Child Ecology, Director, 小児医療研究センター・小児生体研究部, 部長 (90014191)
KOBAYASHI Miyuki  University of Tokyo Hospital, Department of Pediatrics, Assistant Professor, 医学部・附属病院, 講師 (60205391)
HAYASHI Yasuhide  University of Tokyo Hospital, Department of Pediatrics, Assistant Professor, 医学部・附属病院, 講師 (30238133)
YOSHINO Hiroshi  Kyorin University, Department of Pediatrics, Assistant, 医学部, 助手
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
KeywordsPediatric cancer / Familial occurrence / Tumor suppressor genes / Etiological factors / Familial leukemia / Familial cancer / 癌抑制遺伝子 / 小児白血病 / 家族要因 / 疫学 / 分子生物学 / 腫瘍抑制遺子 / MLL遺伝子 / p16遺伝子 / RAS遺伝子
Research Abstract

Objectives : Several evidences showed that some of children's leukemia have their origin in utero and they develop into overt leukemia after one or more additional genetic events. If frequency of mutation is proportional to frequency of DNA replication, active cell division of spermatogonia to produce sperm can accumulate such mutation much more in older male than young male and as the result father of children with leukemia might be older than father of children without cancers. Methods : Data of ages of parents at the time of birth of children with acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), neuroblastoma or hepatoblastoma were provided by the Children's Cancer Registry of Japan. Data of parents of children who visited 5 hospitals for acute illness were served as control. Results : Distribution curves of ages of parents of children with ALL diagnosed at the ages between 2 to 6 years were completely overlapped. Mean ages with SD of father and mother of children with ALL were 383.5 +/- 67.1 months and 348.9 +/- 53.3, respectively. Those of controls were 382.6 +/- 65.3 and 349.4 +/- 54.6, respectively. The results for the children with ALL of other age ranges, AML and embryonal tumors (neuroblastoma, Wilms tumor, hepatoblastoma) were similar. Conclusion : There were no significant differences between ages of either fathers or mothers of children with cancers examined. Hypothesis that older parents might have accumulated carcinogenic mutations in their sperm or ovum was not substantiated.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Kong X-T: "Expression and mutational analysis of the DCC, DPC4 and MADR2 genes in neuroblastoma."Cancer Research. 57. 3772-3778 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohnishi H: "Alteration of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features."Leukemia. 11. 2120-2124 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川村眞智子: "小児急性リンパ性白血病におけるp53遺伝子変異と臨床像."臨床血液. 38. 719-726 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kong X-T: "Alterations of the tumour suppressor gene DCC in neuroblastoma."Eur J Cancer. 33. 1962-1965 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawamura M: "Aleterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia."Leukemia Res. 23. 115-126 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yang H-W: "Pattern of FHIT gene expression itc normal and leukemic cells"Int J Cancer. 81. 897-901 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Guo S-X: "Hypermethylation of p16 and p15 and RB proteint expression in acute leukemia. "Leukemia Research. 24. 39-46 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yang HW: "The p73 gene is less involved in the development but involved in the progression of neuroblastoma."International Journal of Molecular Medicine. 5. 379-384 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Bessho F: "Adult survivors of children's cancer and their offspring."Pediatrics International. 42. 121-125 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohnishi H: "Down syndrome with myelodysplastic syndrome showing t(7;1)(p13;p14)."American Journal Hematology. 33. 1962-1965 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 別所文雄: "Fanconi貧血."日本臨床. 58. 107-112 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] I.Kong X-T, Choi SH, Inouc A, Chen T, Takita J, Yokota J, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, Hayashi Y: "Expression and mutational analysis of the DCC,DPC4 and MADR2 genes in ncuroblastoma"Cancer Research. 57. 3772-3778 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohnishi H.Guo SX, Ida K, Taki T, Naritaka S, Bessho F, Yanagisawa M, Hanada R, Eguchi M, Kamada N, Kita K, Yamamori S, Hayashi Y: "Alteration of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features."Leukemia. 11. 2120-2124 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawamura M, Hayashi Y, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, Horibe K, Hongo T, Ueda K: "Alterations of the p53 gene and clinical features in childhood acute lymphoblastic leukemia."Jpn J Clin Hematol. 38. 719-726 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kong X-T, Choi SH, Inoue A, Takita J, Yokota J, Hanada R, Yamamoto K, Bessho F, Yanagisawa M, Hayashi Y: "Alternations of the tumour suppressor gene DCC in neuroblastoma."Eur J Cancer. 33. 1962-1965 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawamura M, Ohnishi H, Guo S-X, Sheng XM, Minegishi M, Hanada R, Horibe K, Hongo T, Kaneko Y, Bessho F, Yanagisawa M, Sekiya T, Hayashi Y: "Aleterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia."Leukemia Res. 23. 115-126 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yang H-W, Piao YP, Taki T, Chen T, Hashizume K, Ohnishi H, Bessho F, Yanagisawa M, Matsuo Y, Hayashi Y: "Pattern of FHIT gene expression in normal and leukemic cells."Int J Cancer. 81. 897-901 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Guo S-X, Taki T, Ohnishi H, Piao H-Y, Tabuchi K, Bessho F, Hanada R, Yanagisawa M, Hayashi Y: "Hypermethylation of p16 and p15 and RB protein expression in acute leukemia."Leuk Res. 24. 39-46 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yang HW, Piao HY, Chen YZ, Takita J, Kobayashi M, Taniwaki M, Hashizume K, Hanada R, Yamamoto K, Taki Tomohiko, Bessho F, Yanagiasawa M, Hayashi Y: "The p73 gene is less involved in the development but involved in the progression of neuroblastoma."Intern J Mol Med. 5. 379-384 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Bessho F.Kobayashi M.: "Adult survivors of children's cancer and their offspring."Pediatr Intern. 42(2). 121-125 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohnishi H, Taki T, Tabuchi K, Kobayashi M, Bessho F, Hayashi Y: "Down syndrome with myelodysplastic syndrome showing t(7 ; 11)(p13 ; p14)"Am J Hematol. 65. 62-65 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Bessho F: "Fanconi anemia."Jpn J Clin Med. 58. 107-112 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shu-Xia Guo: "Hypermethylation of p16 and p15 and RB protein expression in acute leukemia."Leukemia Research. 24. 39-46 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hong Wei Yang: "The p73 gene is less involved in the development but involved in the progression of neuroblastoma"International Journal of Molecular Medicine. 5. 379-384 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fumio Bessho: "Adult survivors of children's cancer and their offspring"Pediatrics International. 42. 121-125 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hiroaki Ohnishi: "Down syndrome with myelodysplastic syndrome showing t(7;11)(p13;p14)"American Journal of Hematology. 65. 62-65 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 別所文雄: "Fanconi貧血"日本臨床. 58. 1467-1472 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Taki,T.: "ABI-1,a human homolog to mouse Ab1-interactorl,fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11,2;l23)." Blood. 92. 1125-1130 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawamura,M.: "Alterations of the p53,p21,p16,p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia." Leukemia Research. 23. 115-126 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Bessho,F.: "Incidince of neuroblastoma." Lancet. 353. 70 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 別所文雄: "小児の固形腫瘍-最近の進歩.小児固形腫瘍の疫学" 小児内科. 30. 133-141 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 別所文雄: "全国小児がん登録にみる小児白血病の疫学" 小児内科. 29・2. 157-161 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 盛 小明: "小児悪性腫瘍におけるRAS遺伝子の変異・第1編白血病" 日本小児科学会雑誌. 101. 49-56 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ida,Kohmei: "Detection of chimeric in RNAs by reverse trauscriptase polymerase chain reaction for diaguosis and monitoring of acute leukemia with llq23 abuonualities" Medical and Pediatric Oncology. 28. 325-332 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] X-T Kong: "Consistent detection of TLS/FUS・ERG chimeric trauscripts in acute myeloid leukemia with ,t(16;21)(pll;q22)and ideutification of a novel trauscriot" Blood. 90. 1192-1199 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohnishi,Hiroshi: "Altevation of p16 and p15 genes in acute leukemia with MLL gene rearraugemonts and bhetr corrolation with clinical peatures" Leukemia. 11. 2120-2124 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] X-M.Sheng: "Mutation of the RAS genes in childhood acute myeloid leukemia,myelodysplastic syndvane and juvenile chronic myelocrtic leukemia" Leukemia Research. 21. 697-701 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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