• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Problems of safety levels derived from epidemiologic studies using independent variable with measurement error

Research Project

Project/Area Number 09670415
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionToho University

Principal Investigator

SUGITA Minoru  Toho University School of Medicine, Professor, 医学部, 教授 (80051845)

Co-Investigator(Kenkyū-buntansha) OTAHARA Yumi  Toho University School of Medicine, Instructor, 医学部, 助手 (60287498)
IZUNO Takashi  Toho University School of Medicine, Associate Professor, 医学部, 助教授 (20213019)
杉田 稔  東邦大学, 医学部, 教授 (80051845)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
KeywordsDose-response relationship / Independent variable / Measurement error / Ecologic study / Confounding variable / Safety level / Safety level / epidemiology / dose-response relationship / renal dysfunction / cadmium concentration in rice / error in dose / confounding factor
Research Abstract

In epidemiologic or experimental studies for dose-response or -effect relationship between toxic factors and biological responses or effects, parameters which express strength of relationship between independent and dependent variables are usually calculated using statistical models without errors in independent variable. When error in independent variable is not small in study based on individual data, obtained parameter using usual statistical model includes bias toward null relationship between independent and dependent variables i.e. under estimate. When the error in independent variable is not large and the magnitude of the error is known, the methods which correct the under estimate of the parameter were developed. Ecologic study based on means of independent and dependent variables in groups are sometimes conducted in order to decrease effect of error in independent variables. It is, however, pointed out that ecologic study is sometimes carried out without due consideration for confounding factors.
In epidemiologic study for dose-response relationship between renal dysfunction as response and cadmium (Cd) intake calculated from Cd concentration in rice (Cd-R) as dose, error of the dose is very large. Therefore, it is impossible to correct the parameter, which express strength of relationship between independent and dependent variables, using usual statistical model without error in independent variable based on individual data. In the epidemiologic study area, ecologic studies for relationship between means of Cd-R and prevalences of renal dysfunction in Cd polluted and control areas can be carried out. The epidemiologic studies were conducted without due consideration for confounding variable which represents the other environmental factors than Cd-R. Therefore environmental safety level of Cd derived from the epidemiologic studies using Cd-R is not adequate.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Izuno T, Sugita M, Arita S, et al: "Validity of cadmium concentration in rice as the "dose" of the dose-response relationship between cadmium intake and renal dysfunction"(投稿中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 杉田稔: "米中カドミウムと腎機能影響の量・反応関係---米からのカドミウム摂取量はその量として妥当か"環境保健レポート. 65(1). 49-52 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Izuno T, Sugita M, Arita S, Otahara Y, Nasu I, Tsuchiya K, Hayashi Y.: "Validity of cadmium concentration in rice as the "dose" of the dose-response relationship between cadmium intake and renal dysfunction."(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugita M, Arita S, Izuno T, Otahara Y, Shimada N, Takebayashi R, Yoneda M, Hori Y.: "Dose-response relationship between cadmium intake and renal dysfunction --- Is cadmium intake calculated cadmium concentration in rice appropriate as the dose in the dose-response relationship?"Kankyo Hoken Report. 65(1). 49-52 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 杉田稔: "米中カドミウムと腎機能影響の量・反応関係---米からのカドミウム摂取量はその量として妥当か"環境保健レポート. 65(1). 49-52 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Izuno T, Sugita M, Otahara Y,et al.: "Validity of cadmium concentration in rice as the 'dose'of the dose-response relationship between cadmium intake and renal dysfunction" (投稿準備中).

    • Related Report
      1998 Annual Research Report
  • [Publications] Sugita M, Izuno T, Otahara Y, et al.: "Reevaluation of the dose-response relationship between intake of cadmium in rice and renal dysfunction" (投稿準備中).

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi