| Project/Area Number |
09670459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
HARA Kenji Fukuoka Univ., Sch. of Medicine, Lecturer, 医学部, 講師 (00090738)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIMURA Seiichi Fukuoka Univ., Sch. of Med., Professor, 医学部, 教授 (70004710)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Hair analysis / Tyramine / Biogenic compounds / Chemical diagnosis / Mass spectrometry / Gas chromatography / 質量分析法 / 精神分裂病 / 行動異常 / 化学誘導体 |
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| Research Abstract |
Some disease is caused by metabolic disorders. Therefore, biochemical information would play an important role for disorders. There are no adequate reports to diagnose those disorders by biochemical information. To obtain biochemical information, urine and blood are useful in clinical diagnosis. However, the samples should be taken from patients who are diet-controlled for the test. So that, postmortem samples are not suitable for the purpose. Meanwhile, it is said that hair drug analysis is an effective tool for demonstrating chronic drug therapy (or use). Hair collected can be easily preserved under ambient conditions. Our research project was planned based on the hair drug test, if excess biogenic compounds were retained by hair. 1. Gas chromatographic-mass spectrometric analysis together with extractive heptafluoro-n-butyrylation on Extrelut【○!R】 column was employed for acquiring chemical information from hair specimens. In this method, amines, aminophenols were sensitively detected in low level. 2. There were three compounds remarkably detected in hair. No difference among independent, specimens was quantitatively observed in two of them (unidentified). The detections of tyramin (one of them) were quantitatively divided into two different groups. 3. High levels of tyramine in hair were observed in about 30% of total specimens excepting putrefied specimens. Relatively numbers of hair specimens obtained from amphetamine-abusers, heart-disease holders and schizophrenic were observed. By this project work, the future utility of hair analysis is pointed out in resolving metabolic disorders that have so far been veiled.
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