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Study of DMA and DMB as susceptibility genes of SLE, PSS and RA

Research Project

Project/Area Number 09670470
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionThe University of Tokyo

Principal Investigator

TAKEUCHI Fujio  Dept. of Medicine, The University of Tokyo, Lecture, 医学部・附属病院, 講師 (70154979)

Co-Investigator(Kenkyū-buntansha) KUWATA Shoji  Ichihara Hospital, Teikyo University, Dept. of 3rd Medicine, Assistant Professor, 医学部・附属市原病院, 助教授 (00241993)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsRA / SLE / PSS / DMA / DMB / HLA-DR / susceptibility gene / ethnics / 人種差 / 肺繊維症 / TNF / a-Scl-70 / 抗DNA抗体 / C4 / 多型 / 慢性関節リウマチ / HLADR / TAP / 蛋白尿
Research Abstract

In this study, the possibilities were examined that DM genes worked as susceptibility genes of RA, PSS and SLE, and the relationships between DM and clinical features were examined. In normal control (n=77), DMA*0101-0103 and DMB*0101-0103 alleles were observed. A strong positive association was shown between DMA*0102 and DMB*00101. In Japanese, frequencies of DMA*0102 and DMB*0101 were decreased, and those of DMB*0102 and *0103 were increased comparing to Caucasians. The differences in distribution were obvious. In RA (n=91), a frequency of DMB*0101 (52.5%) was sligtly increased. An weak association was observed between DRB1*0405, which was known to be increased in RA, and DMB*0101 ( χィイD12ィエD1=3.02). This inducated that an increase in DMB*0101 in RA was secondary to an increase in DRB1*0405. As disease susceptibility haplotypes, DRBl*0405-[TAP2B-DMA*0102-DMB*0101] would work positively and DRB1*0802-DMB*0103 would work protectively. Examinations of relations to clinical features reve … More aled that a frequency of r-SS Aantibody was higher in DMB*0102 group. (27.3%) and a frequency of an antibody to Ezrin 80KD antigen (61.5% was higher in DMA*0102 group. Moreover, the positivity of proteinuria was higher in DMA*0102 group (44%). No association was observed between the rheumatoid factor and DM. In whole PSS group, a frequency of DMB*0103 was 20.0% and that was decreased comparing to control. The frequencies of DMB*0101 were 70.0% in diffuse scleroderma (DS) and 68.2% in the anti-Scl-70 positive group (Scl), and these frequencies were significantly higher. The significant association was observed between DMB*0101 and DRB1*1502, that was known to be increased in DS and Scl. These observation indicated that the increase in DMB*0101 would be secondary to the increase in DRB1*1502. As a disease susuceptibility haplotype. C4BQ0-DRB1*1502-DMB*0101 was proposed in DS and Scl. A significant negative association was observed between DMB*0103 and lung fibrosis in PSS. Examinations of TNF and HSP-70 showed no significant association to lung fibrosis. In SLE (n=51) no significant difference was observed in frequencies of DMA and DMB alleles comparing to those in control. A frequency of DMB*0101 was increased in the anti-DNA antibody positive group (p=0.045) and the frequency was also slightly higher in SS-A group. In this study, no nobel DM allele was observed. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Park MH, Fujio Takeuchi, et al.: "Association of HLA-DRB1 epitopes and alleles with rheumatoid arthritis in koreans"Genetic Diversity of HLA. II. 660-662 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujio Takeuchi, et al.: "Association of DMA and DMB with RA in Japanese"Clin. Exp. Rheumatol. 15. 189-192 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹内二士夫: "HLAと疾患感受性"免疫.Immunology Frontier. 7. 245-251 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujio Takeuchi, et al.: "Association of DM genes in systemic sclerosis is secondary to the association with HLA genes"Scand J Rheumatol. 26. 174-179 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujio Takeuchi, et al.: "Polymorphisms of DMA and DMB genes in Japanese systemic lupus erythematosus"Bri J Rheumatol. 37. 95-97 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujio Takeuchi, et al.: "C4A and C4B null alleles are genetic markers of different types of systemic sclerosis in Japanese patients"Clin Exp Rheumatol. 16. 55-60 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹内二士夫: "膠原病とhuman leukocyte antigen"日本内科学会誌. 87. 2453-2460 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kodo Shikata, Fujio Takeuchi: "Structural changes in the oligosaccharide moiety of human IgG with aging"Glycoconjugate J. 15. 683-689 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T Wei, Fujio Takeuchi, et al.: "Detection of disease-specific augmentation of abnormal immunoglobulin G in sera of patients with rheumatoid arthritis"Glycoconjugate J.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pandey JP, Fujio Takeuchi: "TNF-α and -β polymorphisms in systemic sclerosis"Human Immunol. 60. 1228-1130 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 滝沢健司、竹内二士夫: "検査の進めかたと個々の疾患の診断、活動性の評価"Medical Practice. 15. 589-598 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 川杉要、竹内二士夫: "発症、進展遺伝子"Pharma Medica. 17. 13-18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹内二士夫(他): "図説 リウマチの物理療法"医学書院 (分担執筆). 120 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹内二士夫: "全身性強皮症"朝倉書店 (内科学第7版、分担執筆). 5 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 竹内二士夫: "結晶性関節炎(リウマチ膠原病のステップアップ診療、分担執筆)"文光堂. 10 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Park MH, Takeuchi F et al.: "Association of HLA-DRB1 epitopes and alleles with rheumatoid arthritis in Koreans."Genetic diversity of HLA. II. 660-662 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F., et al.: "Association of DMA and DMB with RA in Japanese."Clin Exp Rheum. 15. 189-192 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F: "HLA and disease susceptibility."Immunology Frontier. 7 (in Japanese). 245-251 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F., et al.: "Association of DM genes in Systemic Sclerosis is secondary to the associations with HLA genes."Scand J Rheumatol. 26. 174-179 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F., et al.: "Polymorphisms of DMA and DMB genes in Japanese SLE."Brit J Rheumatol. 37. 95-97 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F., et al.: "C4A and C4B null alleles are genetic markers of different types of systemic sclerosis in Japanese patients."Clin Exp Rheum. 16. 55-60 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F: "Collagen disease and HLA."Jap J Medicine. 87 (in Japanese). 2453-2460 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shikata K., Takeuchi F., et al.: "Structural changes in the oligosaccharide moiety of human IgG with aging."Glycoconjugate J. 15. 683-689 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wei T, Takeuchi F., et al.: "Detection of disease-specific augumentation of abnormal immunoglobuline G in sera of patients with rheumatoid arthritis."Glycoconjugate J. 15. 929-934 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takizawa K., Takeuchi F.: "Laboratory examination, disease diagnosis and assessment of disease activity."Medical Practice. 15 (in Japanese). 589-598 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pandey JP, Takeuchi F.: "TNF-α and β polymorphisms in systemicsclerosis."Human Immunol. 60. 1128-1130 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kawasugi K., Takeuchi F.: "Genes for disease onset and prognosis."Pharma Medica. 17 (in Japanese). 13-18 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F.: "Illustrated Physical Therapy of Rheumatoid Arthritis."Igakushoin : (in Japanese). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F.: "Systemic sclerosis, in Internal Medicine, 7th edition, edited by Omata M et al."Asakurashoten (in Japanese). 1161-1121 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeuchi F.: "Crystal induced arthritis, in Step Up Care of Rheumatic Disease, Edited by Goto M."Bunkodo (in Japanese). 215-225 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kodo Shikata ,Fujio Takeuchi et al.: "Structural changes in the oligosaccharide moiety of human IgG with aging"Glycoconjugate J. 15. 683-689 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] T Wei, Fujio Takeuchi et al.: "Detection of disease-specific augumentation of abnormal immunoglobulin G in sera of patients with rheumatoid arthritis"Glycoconjugate J. 15. 929-934 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Pandey JP, Fujio Takeuchi: "TNF-α and -β polymorphisms in systemic sclerosis"Human Immunol. 60. 1128-1130 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 滝沢健司、竹内二士夫: "検査の進めかたと個々の疾患の診断、活動性の評価"Medical Practice. 15. 589-598 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 川杉要、竹内二士夫: "発症、進展遺伝子"Pharma Medica. 17. 13-18 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹内二士夫: "全身性強皮症(内科学第7版、分担執筆)"朝倉書店. 5 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 竹内二士夫: "結晶性関節炎(リウマチ膠原病のステップアップ診療、分担執筆)"文光堂. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujio Takeuchi et al.: "Association of DM genes in systemic sclerosis is secondary to the association with HLA genes." Scand J Rheumatol. 26. 174-179 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujio Takeuchi et al.: "Polymorphisms of DMA and DMB genes in Japanese systemic lupus erythematosus." Bri J Rheumatol. 37. 95-97 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujio Takeuchi et al.: "C4A and C4B null alleles are genetic markers of different types of systemic sclerosis in Japanese patients." Clin Exp Rheumatol. 16. 55-60 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 竹内二士夫: "膠原病とhuman leukocyte antigen" 日本内科学会誌. 87. 2453-2460 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 竹内二士夫(他): "図説 リウマチの物理療法" 医学書院(分担執筆), 120 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujio Takeuchi et al.: "Association of DMA and DMB with RA in Japanese" Cln Exp Rheumatol. 15. 189-192 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 竹内二士夫: "HLAと疾患感受性" 免疫・Immumology Frontier. 7. 245-251 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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