| Project/Area Number |
09670516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Tokyo |
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Principal Investigator |
KOIKE Kazuhiro Tokyo Univ., Dpt of Meddicine, Assosiate Professor, 医学部・附属病院, 助教授 (80240703)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYA Kyoji Tokyo Univ., Dpt of Meddicine, medical Stuff, 医学部・附属病院, 医員
YOTSUYANAGI Hiroshi Tokyo Univ., Dpt of Meddicine, medical Stuff, 医学部・附属病院, 医員
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | hepatitis C / transgenic mice / envelope protein / Siogren syndrome / hepatitis / auto immune disease / sialadenitus / 唾液線炎 / シェ-グレン症候群 |
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| Research Abstract |
Hepatitis C virus (HCV). a major causative agent of non-A, non-B chronic hepatitis, is also suggested to be associated with extrahepatic manifestations such as mixed cryoglobulinemia and glomerulonephritis. Two independent lines of transgenic mice carrying the HCV envelope genes have been previously shown to express the HCV envelope proteins in organs including the liver and salivary glands. which results in no pathological changes in the liver. Further analysis of these animals has now revealed that they develop an exocrinopathy involving the salivary and lachrymal glands. This pathology resembles Sjogren's syndrome, which is also suggested to have a possible association with chronic hepatitis C.These observations suggest that HCV may be involved in the pathogenesis of sialadenitis in humans, and this transgenic mouse system would be a good animal model for the study of HCV infection.
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