| Project/Area Number |
09670589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Fukui Prefectural University College of Nursing |
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Principal Investigator |
KATO Takuji Fokui Prefectural University College of Nursing, Prof., 教授 (70145902)
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Takeshi Fukui Medical University, Assistant Prof, 医学部・附属病院, 講師 (60221040)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Helicobacter pylori / HLA / H.pylori / vacA / 細胞空胞化毒素 / 慢性胃炎 |
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| Research Abstract |
It has been suggested that immunogenetic factors for susceptibility or resistance to disease caused by H.pylon exist in the host. To examine host's genetic factors that increase the risk of gastric adenocarcinoma among H.pylon infected persons, we examined the HLA-DQA1 locus in patients with chronic atrophic gastritis or gastric adenocarcinoma. Eighty two gastric adenocarcinoma patients and 167 unrelated controls were examined for H.pylon infection and HLA-DQA1 genotyping. The allele frequency of DQA1 *0102 was significantly lower in H.pylon-positive patients with atrophic gastritis and in H.pylon-positive patients with gastric adenocarcinoma than in H.pylon-negative normal controls, in H.pylon-positive patients with superficial gastritis, and in H.pylon-negative patients with gastric adenocarcinoma. In addition, the allele frequency of DQAJ *0102 was significantly lower in H.pylon-positive patients with intestinal type gastric adenocaircinoma than in H.pylon-negative patients with diffuse type gastric adenocarcinoma. The HLA-DQA1 *0102 may be important in the etiology of H.pylon associated gastric atrophy. Immunogenetic factors can influence the outcome following H.pylon infection. The DQA1 *0102 allele may contribute to the resistance against H.pylon associated gastric atrophy, and the lack of the DQA1 *0102 allele may be the host's genetic risk factor for H.pylon associated atrophic gastritis and gastric adenocarcinoma.
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