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Mechanisms of life-shrecthening attacks of asthma.

Research Project

Project/Area Number 09670592
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

KIKUCHI Yoshihiro  Tohoku University School of Medicine, lecturer, 医学部, 講師 (20195217)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsBronchial asthma / Death from asthma / Dyspnea / hypoxia / beta2-stimulant inhalation / β刺激剤吸入
Research Abstract

The purpose of the present was to examine the precise mechanisms of death from asthma attacks. Specifically, I intended to clarify my hypothesis that an increase in physical activity and/or an inhalation of beta2-stimulant during an exerbation of asthma maybe a trigger of unconsciousness, leading to death.
Main findings in this project were as follows.
1. I interviewed to 28 patients with near-fatal asthma, who had in experience of unconsciousness during an attack or had received treatment with a mechanical ventilator. Sixty-eight percent of their near-fatal episodes had occurred just after the increasing physical activity, in particular walking, and 17 percent had occurred after/or during the inhalation of beta2-stimulant through an ultrasonic nebulizer. These results suggest that the increase in physical activity and the inhalation of beta2-stimulant during an exerbation of asthma may be a trigger of unconsciousness, leading to death.
2 It was also demonstrated that both the increase physical activity and the inhalation of beta2-stimulant decreased in arterial oxygen saturation during an exacerbation of asthma. The more severe airway bronchoconstriction expressed by peak expiatory flow was, the more oxygen saturation decreased by an inhalation of beta2-stimulant.
3. It was demonstrated that doxapram increases the perception of dyspnea during breathing through resistances as well as hypoxic ventilatory response. This suggest that doxapram may improve the two risk factors, i.e. blunted perception of dyspnea and lower edhypoxic ventilatory response, of patients with near-fatal asthma. This drug may be useful for a treatment for patients with near-fatal asthma.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Midorikawa ら: "Lack of ventilatory threshold in patients with chronic obstructive pulmonary disease" Respiration. 64. 76-80 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ebihara ら: "Role f cyclic ADP-ribose in ATP-activated potasium currents in alveolar macrophages." J.Biol chem. 272. 16023-16029 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taguchi ら: "Improvement of exercise performance with short-term nasal continnous positive airway pressure in patients with obstructive sleep apnea" Tohoku J Exp Med. 183. 43-45 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shindoh ら: "Effects of L-NAME and L-arginine on diaphragm contraction in a septic animal model" Comp Biochem Physiol. 119. 219-224 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chonan ら: "Influence of sustained hypoxia on the sensation of disprea" Japane Journal of Physiology. 48. 291-295 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ebihara ら: "Effects of doxapram on the perception of dyspnea and the hypoxic ventilatory response." Eur Respin J. 発表予定.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三嶋理晃ら: "肺気腫" 金芳堂, 283 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川上義和ら: "呼吸調節のしくみ-ベッドサイドへの応用" 文光堂, 287 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Midorikawa J,Hida W,.Taguchi O,Okabe S,Kurosawa H,Mizusawa A,Ogawa H,Ebihara S,Kikuchi Y,Shirato K.: "Lack of ventilatory threshold in patients with chronic obstructive pulmonary disease." Respiration. 64. 76-80 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ebihara S,Sasaki T,Hida W,Kikuchi Y,Oshiro T,Shimura S,Takasawa S,Okamoto H,Nishiyama A,Akaike N,Shirato K.: "Role of cyclic ADP-ribose in ATP-activated potasium currents in alveolar macrophages" J Biol Chem. 272. 16023-16029 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taguchi O,Hida W,Okabe S,Ogawa H,Kikuchi Y,Shirato K.: "Improvement of exercise performance with short-term nasal continuous positive airway pressure in patients with obstructive sleep apnea." Tohoku J Exp Med. 183. 43-45 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shinndoh C,Wu D,Ohuchi Y,Kurosawa H,Kikuchi Y,Hida W,Shirato K.: "Effects of L-NAME and L-arginine on diaphragm contraction in a septic animal model." Comp Biochem Physiol. 119. 219-224 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chonan T,Okabe S,Hida W,Satoh M,Kikuchi Y,Takishima T,Shirato K.: "Influence of sustained hypoxia on the sensation of dyspnea." Jap J Physiol. 48. 291-295 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ebihara S,Kikuchi Y,Ogawa H,Kurosawa H,Okabe S,Hida W,Shirato K.: "Effects of doxapram on the perception of dyspnea and the hypoxic ventilatory response." Eur Respir J. (in Press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chonanら: "Influence of sustained hypoxia on the sensation of dyspres" Japanese Journal of Physiology. 48. 291-295 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ebihara S.ら: "Effects of doxapram on the perception of dyspnea and the hypopic ventilatory response" Eur Respin J. 発表予定. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三嶋理晃ら編集: "肺気腫" 金芳堂, 283 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shindoh ら: "Effects of L-NAME and L-arginine on diaphragm contraction in a septic animal model." Conp.Biochem.Physiol. 119(1). 219-224 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Taguchi et al.: "Improvement of execise partonmance with shert-term nasal continuous positive airway pressuce in patients with obstvnitive slosp apian." Tohoku J Exp Met. 183. 43-45 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ebihara et al.: "Role of cyclic ADP-ribcse in ATP-activeted potasium carrewts in alveclar macrophages" J Biol Chem. 272. 16023-16029 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Midorikawa et al.: "Lacle of ventilatory thveshold in patient with clrom-obstrctive pulwonary lesease." Regiration. 64. 76-80 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川上義和編集: "呼吸調節のしくみ-ベッドサイドへの応用" 文光堂, 287 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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