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RESEARCHES INTO THE EFFECTS OF ORGANIC DUST ON THE LUNGS AND THE PATHOGENIC MECHANISMS

Research Project

Project/Area Number 09670623
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

NAKAGAWA Kazuko  KUMAMOTO UNIVERSITY,GRADUATE SCHOOL OF PHARMACY,ASSOCIATE PROFESSOR, 薬学研究科, 助教授 (20284747)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsoccupational lung diseases / organic dust / Penicillium / polymerase chain reaction / Trichosporon / fungal infection / hypersensitivity pneumonitis / pulmonary finrosis / polimerase chain reaction / 肺繊維症 / Trichosporpn
Research Abstract

1. Background : The health hazards associated with organic dust exposure have been recognized for several centuries, whereas the pathogenic mechanisms are difficult to define precisely.
2. Objectives : We investigated the effects of organic dust on the lungs and the pathogenic mechanisms, with an object of searching for new methods of diagnosis, therapy and prevention.
3. Methods : We have done (1) a medical examination of farmers in Taiki, Hokkaido, by questionnaire, a chest radiograph, physical examinations and serum antibodies to the organic dust. (2) We examined the dust and clinical samples in vitro by mycological, immunological and polymerase chain reaction (PCR) methods. (3) We developed murine models for experimental therapy.
4. Results : (1) We revealed that 20% of farmers in Taiki show abnormalities of their chest radiographs. We identified 14 cases of hypersensitivity pneumonitis (HP), including a fulminate case. Most of them have serum antibodies to the dust or fungi of their own environment but not to commercially available antigens for the diagnosis of HP.(2) We applied PCR to detect causative agent specific DNAs in host and environment in HP.It may be a new method to investigate the pathogenic mechanisms of fungi in organic dust. We identified four Penicillium species as new antigens of HP.(3) We developed murine models of HP and trichosporonosis using standard strains for Trichosporon antigen, and proved a common pathogenesis of Trichosporon inducing hypersensitivity and infection, depending of the immunological status of the host. The therapeutic dosage of erythromycin significantly suppressed acute neutrophils influx into the lung, intradermal Arthus reaction and the expression of ICAM-1 in the lesions of the experimental HP.
5. Conclusions : We confirmed the pathogenicity of fungi in organic dust and proposed possible new methods for diagnosis and therapy for the pulmonary diseases caused by them.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Kazuko Nakagawa-Yoshida, et al.: "Fatal cases of farmer's lung in a Canadian family:probable new antigens, Penicillium brevicompactum and P. olivicolor." Chest. 111. 245-248 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muranaka H, Suga M, Sato K, Kazuko Nakagawa, et al.: "Superoxide scavenging activity of erythromycin-iron complex." Biochem. Biophys. Res. Commun. 232. 183-187 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishiura Y, Kazuko Nakagawa-Yoshida, et al.: "Assignment and serotyping of Trichosporon species, the causative agents of summer-type hypersensitivity pneumonitis." J Med Vet Mycol. 35. 45-52 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chul-Gyu Y, Kim YW, Han SK, Kazuko Nakagawa-Yoshida: "Summer-type hypersensitivity pneumonitis outside Japan:a case report and the state of the art." Respirology. 2. 75-77 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suga M, Yamasaki H, Kazuko Nakagawa, et al.: "Mechanisms accounting for granulomatous responses in hypersensitivity pneumonitis." Sarcoidosis Vasculitis and Diffuse Lung Diseases. 14. 131-138 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muranaka H, Suga M, Kazuko Nakagawa, et al.: "Effects of granulocyte-and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis." Infect Immun. 65. 3422-3429 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa K, et al.: "Occupational hypersensitivity pneumonitis in Japan." In:K. Chiyotani, et al eds. Advances in the Prevention of Occupational Respiratory Diseases. Excerpta Medica International Congress Series. 1153. 439-444 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa K, et al.: "Detection of Trichosporon in host and environment by polymerase chainreaction(PCR):a new diagnostic approach to hypersensitivity pneumonitis or infection" In:K. Chiyotani, et al eds. Advances in the Prevention of Occupational Respiratory Diseases. Excerpta Medica International Congress Series. 751-755 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Moris, K. Nakagawa-Yoshida, et al.: "Mushroom worker's lung resulting from indoor cultivatio of Pleurotus osteatus." Occup Med. 48. 465-468 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中川和子他: "薬物による間質性肺炎" 臨床医. 24. 2425-2429 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyajima M, Suga, M, Nakagawa K, et al.: "Effects of erythromycin on experimental extrinsic allergic alveolitis." Clin Exp Allergy. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa Y, Shimazu K, Ebihara M, Nakagawa K: "A case of Aspergillus niger pneumonia with fatal pulmonary oxalosis." J Infect Chemother. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa-Yoshida, K., et al.: "Fatal cases of farmer's lung in a Canadian family : Probable new antigens, Penicillium brevicompactum and P.olivicolor." Chest. 111. 245-248 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muranaka, H., et al.: "Superoxide scavenging activity of erythromycin-iron complex." Biochem Biophys Res Commun. 232. 183-187 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishiural, Y., et al.: "Assignment and serotyping of Trichosporon species the causative agents of summer-type hypersensitivity pneumonitis" J Med Vet Mycol. 35. 45-52 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chul-Gyu, Y., et al.: "Summer-type hypersensitivity pneumonitis outside Japan : a case report and the state of the art." Respirology. 2. 75-77 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suga, M., et al.: "Mechanisms accounting for granulomatous responses in hypersensitivity pneumonitis." Sarcoidosis Vasculitis and Diffuse Lung Diseases. 14. 131-138 (1977)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muranaka, H., et al.: "Effects of ganulocyte- and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis" Infect Immun. 65. 3422-3429 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa, K., et al.: "Occupational hypersensitivity pneumonitis Japan." In : K.Chiyotani, et al eds.Advances in the Prevention of Occupational Respiratory Diseases.Excerpta Medica International Congress Series. 1153. 439-444 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa, K.et al.: "Detection of Trichosporon in host and environment polymerase chain reaction (PCR) : a new diagnostic approach to hypersensitivity pneumonitis or infection." In : K.Chiyotani, et al eds.Advances in the Prevention of Occupational by Respiratory Diseases.Excerpta Medica International Congress Series. 1153. 751-755 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mori, S., et al.: "Mushroom worker'S lung resulting from indoor cultivatio of Pleurotus osteatus." Occup Med. 48. 465-468 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyajima, M., et al.: "Effects of erythromycin on experimental extrinsic allergic alveolitis." Clin Exp Allergy. 29. 253-261 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa, Y., et al.: "A case of Aspergillus niger pneumonia with fatal pulmonary oxalosis." J Infect Chemother. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa K,et al.: "Occupation hypersensitivity pneumonitis in Japan." In:K.Chiyotani,et al eds.Advances in the Prevention of Occupational Respiratory Diseases. Excerpta Medica International Congress Series. 1153. 439-444 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakagawa K,et al.: "Detection of Trichosporon in host and environment by polymerase chainreaction(PCR):亜new diagnostic approach to hypersensitivity pneumonitis or infection." In:K.Chiyotani,et al eds.Advances in the Prevention of Occupational Respiratory Diseases. Excerpta Medica International Congress Series. 751-755 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Moris,K. Nakagawa-Yoshida,et al.: "Mushroom worker's lung resulting from indoor cultivatio of Pleurotus osteatus." Occup Med. 48. 2425-2429 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中川和子他: "薬物による間質性肺炎" 臨床医. 2425-2429. 2425-2429 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Miyajima M,Suga,Nakagawa K,et al.: "Effects of erythromycin on experimental extrinsic allergic alveolitis." Clin Exp Allergy. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakagawa Y,Shimazu K,Ebihara M,Nakagawa K: "A case of Aspergillus niger pneumonia with fatal pulomonary oxalosis." J Infect Chemother. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中川和子他: "薬剤誘起肺疾患・最近の問題:発生頻度・疫学" The Lung Perspectives. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kazuko Nakagawa-Yoshida, et al.: "Fatal cases of farmer's lung in a Canadian family : probable new antigens, Penicillium brevicompactum and P. olivicolor." Chest. 111. 245-248 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Muranaka H, Suga M, Sato K, Kazuko Nakagawa, et al.: "Superoxide scavenging activity of erythromycin-iron complex." Biochem Biophys Res. Commun. 232. 183-187 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishimura Y, Kazuko Nakagawa-Yoshida, et al.: "Assignment and serotyping of Trichosporon species, the causative agents of summer-type hypersensitivity pneumonitis." J Med. Vet Mycol. 35. 45-52 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Chul-Gyu Y, Kim YW, Han SK, Kazuko Nakagawa-Yoshida: "Summer-type hypersensitivity pneumonitis outside Japan : a case report and the state of the art." Respirology. 2. 75-77 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suga M, Yamasaki H, Kazuko Nakagawa, et al.: "Mechanisms accounting for granulomatous responses in hypersensitivity pneumonitis." Sarcoidosis Vasculitis and Diffuse Lung Diseases. 14. 131-138 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Muranaka H, Suga M, Kazuko Nakagawa, et al.: "Effects of granulocyte- and granulocyte-macrophage colony-stimulating factors in a neurotopenic murine model of trichosporonosis." Infect Immun. 65. 3422-3429 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuko Nakagawa, et al.: "Occupational hypersensitivity pneumonitis in Japan." In : K. Chiyotani ed. 9th International Conference on Occupational Respiratory Diseases. Kyoto 13-16 October, 1997, Excerpta Medica International Congress Series.1153 (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuko Nakagawa, et al.: "Detection of Trichosporon in host and environment by polymerase chain reaction (PCR) : a new diagnostic approach to hypersensitivity pneumonitis or infection" In : K. Chiyotani ed. 9th International Conference on Occupational Respiratory Diseases. Kyoto 13-16 October, 1997, Excerpta Media International Congress Series.1153 (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mori S, Kazuko Nakagawa-Yoshida, et al.: "Mushroom worker's lung resulting from indoor cultivation of Pleurotus osteatus." Occup Med. (in press). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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