| Project/Area Number |
09670626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | DOKKYO UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
UEDA Takashi Dokkyo University School of Medice, Lecturer, 医学部, 講師 (80213354)
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| Co-Investigator(Kenkyū-buntansha) |
SERIZAWA Yoshimoto Instructor, 医学部, 助手 (60306181)
NAKAZIMA Hirokazu Instructor, 医学部, 助手 (10275753)
有馬 雅史 獨協医科大学, 医学部, 助手 (00202763)
浅川 潤一 獨協医科大学, 医学部, 助手 (80285816)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Surfactant / Surfactant Protein A / injury lung / Bronchial Asthma / Chemotactis activity / Apoptosis / Eosinophil / Cytokine / 気道上皮 / GM-CSF / 脱顆粒 |
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| Research Abstract |
We investigated suffactant system in acute lung injury and asthmatic lungs. We found that suffactant protein A (SP-A) could stimulate chemotaxis of bronchial epithelial cells, suggesting that SP-A might play a role in lung repair following injury as a chernoattractant. We also reported that altered surfactant system and metabolism in rat lungs injured by LPS instillation. We also reported compositional and functional changes of surfactant in a guinea pig model of chronic asthma and increased levels of SP-A in the airway in patients with bronchial asthma. The interactions between surfactant and eosinophils were also studied. We demonstrated surfactant could induce apoptosis of eosinophils, surpress IL-8production by eosinophils and inhibit ECP degranulation. All these new findings must open a new array to study the involvement of surfactant in the pathogenesis of bronchial asthma and acute lung injury.
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