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Study on regulatory T cells in inflammatory demyelinating disease

Research Project

Project/Area Number 09670674
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTokyo Women's Medical School

Principal Investigator

OHA Kohei  Tokyo Women's Medical University, Dept. of Neurology, 医学部, 講師 (00152132)

Co-Investigator(Kenkyū-buntansha) AKIYAMA Naoko  Tokyo Women's Medical School, Dept. of Neurology, 医学部, 助手 (00256588)
SHIMIZU Yuki  Tokyo Women's Medical School, Dept. of Neurology, 医学部, 助手 (20246507)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsVα24+T cell / Natural killer T cell / Th1 cells / Th2 cells / Multiple sclerosis / Chronic inflammatory demyelinating polyneuropathy / Gullain-Barre Syndrome / Immunoadsorption therapy / multiple sclerosis / immune regulation / NKT cell / leulcocyte activation / immunoadsorbent therapy / chronic inflammatory demyelirating polyneuropathy / T helper 1 cell / T helper 2 cell / immuno adosorbent therapy / Mac-1 / L-selectin / myelin basic protein / anti-ergotypic T cell / anti clouotypic T cell / immune vegulation
Research Abstract

1) Vα24+ regulatory T cell in inflammatory demyelinating disease
Vα+24T cells produced IFN-γ and IL-4 may have regulary mechanism, we therefore measured positive percentage of peripheral blood Vα24+T cells in patient with neuroimmunological disorders. A positive percentage of Vα24+T cells in multiple sclerosis(MS), chronic inflammatory demyelinating polyneuropathy (CIDP) and Gullain-Barre syndrome was not significant however fine analysis by double stain of anti- Vα24 and Vβ11 antibodies and further examinations considered the stage or treatment of a patient may necessary to determine the role of Vα24+T cells in inflammatory demyelinating diseases.
2) Immunoregulatory cytokine producing T cell in inflammatory demyelinating disease
We Examined IFN-γ and IL-4+T cells in inflammatory demyelinating diseases because the regulatory mechanism between Th1 and Th2 cells takes important role in experimental auto immune encephalomyelitis. The positive percentage of IFN-γ+CD4 cell in the exacerbation … More of MS showed a tendency of increase and decrement of IFN-γ+CD4 cell was noted in some MS patients after steroid therapy. It was suggested the regulatory mechanism between Th1 and Th2 cells might be changed by the condition of a MS patient.
3) IL-2 reactive natural killer (NK) γδT cell in MS
Peripheral blood γδT cells associated with CD56 may play a regulatory role in the disease because they are sensitive and to IL-2 and sometimes take a high value in MS patiensts. When we examined dynamics of NKγδT cells in MS patients to determine their importance in the immune response, the variation of positive percentage and cytotoxicity of NKγδT cells was recognized by a stage of a disease. Thus, the possibility that NKγδT cell might influence to the pathogenesis of MS was suggested.
4) Neutrophil activation in immunoadsorption
To define the influence of Immunoadsorption therapy (IAT) on leukocytes, we determined leukocytes L-selectin and Mac-1 during CIDP during IAT. Expression of neutophils (PMN) L-selctin was significantly decreased and PMN Mac-l was markedly increased by IAT, while expression of mononuclear cells (MNC) L-selectin slightly increased during IAT and MNC Mac-1 was not changed during IAT. L-selectin downregulation and Mac-1 upregulation on PMN suggested that activation of PMN associated with changes in peripheral leukocytes distribution occurred during IAT and might play some role in modulating immune system. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] K, Ota et al: "Neutrophil activation in immunoadsorption"Therapeutic Aphenesis. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 植田美加,太田宏平 他: "慢性炎症性脱髄性多発ニューロパチーに対するインターフェロン-α2a治療"臨床神経学. 40(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水優子,太田宏平 他: "免疫グロブリン大量療法を施行した慢性炎症性脱髄性多発ニューロパチー患者未梢血リンパ球"神経免疫学. 8・1. 132-133 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 太田宏平 他: "Myelopathyを呈したidiopathic CD4+t-lywphocytopenia"神経免疫学. 6・1. 166-167 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 太田宏平: "免疫吸着療法における白血球の活性化"神経免疫学. 6・2. 47-53 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水優子,太田宏平 他: "神経免疫疾患における免疫吸着療法時の隨伊症状について"神経免疫学. 6・1. 92-93 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水優子,太田宏平 他: "多発性硬化症の未梢血IL-2反応性CD56+γδT細胞の変化について"日本免疫学会総会・学術集会記録. 28. 135 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 太田宏平 他: "Myelin oligodendro cyte glyco Drotein(MOG)に反応するヒト由来T細胞*"日本免疫学会総会・学術集会記録. 27. 341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Ota et al.: "Neutrophil activation in immunoadsorption."Therapeutic Apheresis. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Ueda, K.Ota et al.: "Treatment with interferon-α2a in a patient with chronic inflammatory demyelinating polyneuropathy."ClineNeurol (Japan). 40(in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Shimizu, K.Ota et al.: "The changes in the peripheral blood lymphocyte subsets after high dose intravenous immunoglobulin therapy in patients with chronic inflammatory demelinating polyneuropathy."Neuroimmuol. 8. 132-133 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Ota et al.: "Idiopathic CD+T-lymphocytopenia associated with myelopathy."Neuroimmuol. 6. 166-167 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Ota et al.: "Leukocyte activation in immunoadsorbent therapy."Neuroimmoul. 6. 47-53 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Shimizu, K.Ota et al.: "Complications during immunoadsorbent therapy in neuroimmunoligical diseases."Neuroimmuol. 6. 92-93 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Shimizu, K.Ota et al.: "Peripheral blood IL-2 reactive CD56+γδT cell in multiple sclerosis."Proc Jpn Soc Immunol. 28(abst). 135 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Ota et al.: "Myelin oligodendrocyte glycoprotein reactive T cell in multiple sclerosis."Proc Jpn Soc Immunol. 27(abstr). 341 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K OTA et al: "Neutrophil activation in immunoadsorption"Therapeutic Apheresis. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清水優子 他: "免疫グロブリン大量療法を施行した慢性炎症性脱髄性多発ニューロパチー患者末梢血リンパ球サブセットの変化について"神経免疫学. 81. 132-133 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 植田美加,太田宏平 他: "慢性炎症性脱髄性多発ニューロパチーに対するインターフェロン-α2a治療"臨床神経学. 40・2(印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 太田宏平: "免疫吸着法における白血球の活性化" 神経免疫学. 6・2. 47-53 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 太田宏平: "免疫吸着療法における白血球L-selectinとMac-1の変動" 日本免疫学会総会・学術集会記録. 28. 264 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 清水優子: "多発性硬化症の末梢血IL-2反応性CD56^+γ8T細胞の変化について" 日本免疫学会総会学術集会記録. 28. 135 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 太田宏平: "Myelin oligodentlrocyte glycoprotein(MOG)に反応するヒト由来T細胞株" 日本免疫学会総会・学術集会記録. 27. 341 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 清水優子: "多発性硬化症の末梢血γδT細胞の増殖因子およびその機能について" 日本免疫学会総会・学術集会記録. 27. 341 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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