Relation between Fluctuation of Activation Sequence and Arrhythmogenecity in Sodium Channel Blocker
| Project/Area Number |
09670690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
SHIRAKABE Masanori Yamagata University School of Medicine, Assistant Professor, 医学部, 助手 (10241697)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOYA Yukio Yamagata School of Medicine, Health Science, 助教授 (10250945)
YAMAKI Michiyasu Yamagata University, School of Medicine, Assistant Professor, 医学部, 助手 (40191217)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | principal component analysis / ventricular fibrillation / antiarrhythmic drug / flecainide / ST alternans / リエントリ- / 虚血再灌流 |
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| Research Abstract |
To examine correlation between fluctuation of activation sequence and arrhythmogenecity, we investigated temporal changes in activation sequence by measuring activation times (-dV/dt in QRS) from the entire heart in 18 dogs. A heart was constantly paced by atrial stimulation. Character of fluctuated activation sequence was established by a principal component analysis, in which the first principal component was defined as a stable component of the sequence, the second or third as a fluctuated component. Steady state contained 2.2 * 0.6% (percent to total principal component, mean *** SD) of fluctuated components, which appeared in a beat-by-beat manner (activation-sequence alternans). Activation-sequence alternans was observed only during flecainide administration, but not during lidocaine or disopyramide. Fluctuated componcnts at a high-dose of flecainide was 3.3 *** 0.8% (p < 0.05 vs. control). Ventricular fibrillation ensued in all dogs after the increase in activation-sequence alternans. In conclusion, flecainide evoked local activation-sequence alternans. This phenomenon was correlated with the occurrence of ventricular fibrillation.
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Report
(3 results)
Research Products
(10 results)
