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Relation between Fluctuation of Activation Sequence and Arrhythmogenecity in Sodium Channel Blocker

Research Project

Project/Area Number 09670690
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYamagata University

Principal Investigator

SHIRAKABE Masanori  Yamagata University School of Medicine, Assistant Professor, 医学部, 助手 (10241697)

Co-Investigator(Kenkyū-buntansha) HOSOYA Yukio  Yamagata School of Medicine, Health Science, 助教授 (10250945)
YAMAKI Michiyasu  Yamagata University, School of Medicine, Assistant Professor, 医学部, 助手 (40191217)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsprincipal component analysis / ventricular fibrillation / antiarrhythmic drug / flecainide / ST alternans / リエントリ- / 虚血再灌流
Research Abstract

To examine correlation between fluctuation of activation sequence and arrhythmogenecity, we investigated temporal changes in activation sequence by measuring activation times (-dV/dt in QRS) from the entire heart in 18 dogs. A heart was constantly paced by atrial stimulation. Character of fluctuated activation sequence was established by a principal component analysis, in which the first principal component was defined as a stable component of the sequence, the second or third as a fluctuated component. Steady state contained 2.2 * 0.6% (percent to total principal component, mean *** SD) of fluctuated components, which appeared in a beat-by-beat manner (activation-sequence alternans). Activation-sequence alternans was observed only during flecainide administration, but not during lidocaine or disopyramide. Fluctuated componcnts at a high-dose of flecainide was 3.3 *** 0.8% (p < 0.05 vs. control). Ventricular fibrillation ensued in all dogs after the increase in activation-sequence alternans. In conclusion, flecainide evoked local activation-sequence alternans. This phenomenon was correlated with the occurrence of ventricular fibrillation.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report

Research Products

(10 results)

All Other

All Publications (10 results)

  • [Publications] Yamaguchi S, et al.: "Elevated circulating levels and cardiac secretion of soluble Fas ligand in patients with congestire heart failure." American Journal of Cardiology. 84 in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tachibana H,et al.: "Effects of activation sequence on monophasic action potential configuration in the dog." J Electrocardiol. 30(1). 65-70 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo T,et al.: "Electrophysiological effects sodium channel blockable on anisotropic conduction and conduction block in canine myocardium." J Am Coll Cardiol. 29(7). 1639-1644 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nozaki N,et al.: "Soluble tumor necrosis factor receptors are elevated in relation to severity of congestive heart failure." Jpn Circ J. 61(8). 657-664 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okuyama M,et al.: "Serum levels of soluble form of Fas molecule in patients with congestive heart failure." Am J Caridol. 79. 1698-1701 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamaguchi S,et al.: "Elevated circulating levels and cardiac secretion of soluble Fas ligand in patients with congestive heart failure." Am J Caridol. 84(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamaguchi S, et al.: "Elevated circulating lerels and cardiac secretion of soluble Fas ligand in patients with congestire heart failure." American Journal of Cardiology. 84 in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tachibana H., et al: "Effects of activation sequence on monophasic action potential configuration on the dog" Journal of Electrocardiology. 30・1. 65-70 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kondo T., et al: "Electrophysiologic effects of sodium channel blockade on anisotropic conduction and conduction block in carine myocadium" Joornal of the Amevrcan College of Cardiology. 29・7. 1639-44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tachibana H., et al: "Discordant ST alternans contributes to formation of ve-entry" American Journal of physiology. (発表予定). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-03-31   Modified: 2016-04-21  

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