| Project/Area Number |
09670701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Tokyo |
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Principal Investigator |
SUZUKI Jun-ichi University of Tokyo, Health Servoce Center, Assistant Professor, 保健管理センター, 講師 (50260485)
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| Co-Investigator(Kenkyū-buntansha) |
TOYO-OKA Teruhiko University of Tokyo, Health Servoce Center, Professor, 保健管理センター, 教授 (00146151)
西川 潤一 東京大学, 医学部・附属病院, 助教授 (00010322)
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| Project Period (FY) |
1997 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | wall shear stress / maqnetic resonance velocity mapping / atheroscrelosis / magnetic resonance imaging |
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| Research Abstract |
Low wall shear stress and its large oscillation accelerate atherosclerotic process. Wall shear stress is the product of wall shear rate and blood viscosity coefficient. It has been impossible to measure in vivo wall shear rate that is defined as spatial derivative of near wall blood flow velocity. Magnetic resonance velocity mapping can provide digital information on blood flow velocity for each pixel. Therefore, with this technique the following results were obtained by analyzing three-dimensional vector of wall shear rate.
1) At the inner wall of the distal portion of the aortic arch, the shear rate was smallest and the oscillation was largest indicating that this anatomical portion was the most susceptible to hemodynamical atherogenesis.
2) At the bifurcation of the abdominal aorta, outer wall shear rate was smaller than inner one, and oscillation of outer wall shear rate was larger than that of inner wall shear rate demonstrating the higher risk of atherogensis at the outer wall of the bifurcation.
Thus three-dimensional vector analysis of wall shear rate with magnetic resonance velocity mapping can noninvasively detect the high rist portion susceptible to atherosclerosis.
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