• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Modulation of cardiac potassium channels in pathological conditions and developments

Research Project

Project/Area Number 09670710
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

KAMIYA Kaichiro  Nagoya Univ.Res.Inst.of Environ.Med., Associate Professor, 環境医学研究所, 助教授 (50194973)

Co-Investigator(Kenkyū-buntansha) KANBE Fukushi  Nagoya Univ.Res.Inst.of Environ.Med., Associate Professor, 環境医学研究所, 助教授 (00211871)
YASUI Kenji  Nagoya Univ.Res.Inst.of Environ.Med., Associate Professor, 環境医学研究所, 助手 (70283471)
外山 淳治  名古屋大学, 環境医学研究所, 教授 (20023658)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Keywordsthyroid hormone / action potential / potassium channels / gene / cardiac hypertrophy / ion channels / アミオダロン
Research Abstract

In this study. we examined the modulation of cardiac potassium channels in various types of pathological conditions and during developmental changes. Possible role of gene regulation of channels was also examined. Levels of K channel mRNA.levels of channel protein, spatial distribution channel protein and ion currents were observed in cultured cardiac myocytes or hypertrophied hearts. Main findings obtained during this grant were :
1) Thyroid hormone exhibit diffeerent effects on each cardiac channels.
2) The prolongation of action potential duration in monocrotalin-induced right ventricular hypertrophy was caused initially by increase in calcium current and lately by decrease in transient outward current.
3) Effects on cardiac channels were dependent on the types of cardiac hypertrophy. differently modulated depends.
All of above findings have already accepted to publish in journals listed later.
The molecular methods used in this study were all developed in these ten years. These remarkable progresses in methodology may lead to further understanding of channel behavior in diseased hearts.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Kamiya K.,YOSHIDA S.,HOJO M.et al.: "Acute effects of amiodarone on E-4031-sensitive (I_<Kr>) and 293B-sensitive (I_<Ks>) components of delaved rectifier potassium channels in rabbit ventricular myocytes." Environmental Medicine. 42. 128-130 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NISHIYAMA A.,KAMBE F.,KAMIYA K.,et al.: "Effects of thyroid status on expression of voltage-gated potassium channels." Cardiovascular Research. 40. 343-351 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO W.,KAMIYA K.,HOJO M.,et al.: "Regulation of Kv4.2 and Kv1.4 K^+ channel expression by myocardial hypertrophic factorsin cultured newborn rat ventricular cells." Journal of Molecular Cellular Cardiology. 30. 1449-1455 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO W.,KAMIYA K.,KADA K.,et al.: "Regulation of cardiac Kv1.5 K^+ channel expression by cardiac fibroblasts and mechanical load in cultured newborn rat ventricular myocytes." Journal of Molecular Cellular Cardiology. 30. 157-166 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO W.,KAMIYA K.,KODAMA I.,et al.: "Cell cycle-related changes in the voltage-gated Ca^<2+> currents in cultured newborn rat ventricular myocytes." Journal of Molecular Cellular Cardiology. 30. 1095-1103 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO W.,KAMIYA K.,YASUI K.,et al.: "α_1-Adrenoceptor agonists and IGF-1,myocardial hypertrophic factors,regulate the Kv1.5 K^+ channel expression differentially in cultured newborn rat ventricular cells." European Journal of Physiology. 436. 26-32 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KAMIYA K.,GUO W.,TOYAMA J.,et al.: "Modulation of potassium channels by chronic hypoxia in neonatal rat cultured ventricular myocytes." Environmental Medicine. 41. 60-62 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] LEE JK.,KODAMA I.,HONJO H.,et al.: "Stage-dependent changes in membrane currents inrats with monocrotaline-induced right ventricular hypertrophy." American Journal of Physiology. 272. 2833-2842 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NISHIYAMA A.,KAMBE F.,KAMIYA K.,et al.: "Effects of thyroid and glucocorticoid hormones on Kv1.5 potassium channel gene expression in the rat left ventricle." Biochemical and Biophysical Research Communications. 237. 521-526 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO W.,KAMIYA K.,LIU W.,et al.: "Developmental changes of the ultrarapid delayed rectifier K^+ current in rat ventricular myocytes." European Journal of Physiology. 433. 442-445 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOYAMA Junji, KAMIYA Kaichiro, CHENG Jianhua, LEE Jong-kook, SUZUKI Ryoko, KODAMA Itsuo: "Vesnarinone prolongs action potential duration without reverse frequency dependence in rabbit ventricular muscle by blocking the delaydrectifier K^+ current." Circulation. 96. 3696-3703 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, LIU Weiran, TOYAMA Junji: "Developmental changes of the ultrarapid delayd rectifier K+ current in rat ventricular myocytes." European Journal of Physiology. 433. 442-445 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, TOYAMA Junji: "Evidences of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes." Journal of Mollecular Cellular Cardiology. 29. 617-627 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KADA Kenji, KAMIYA Kaichiro, TOYAMA Junji: "IGF-I regulates K+ channel expres of cultured neonetal rat ventricular myocytes." American Journal of Physiology. 272. H2599-2606 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, TOYAMA Junji: "Roles of the voltage-gated K+ channel subunits, Kv1.5 and Kv1.4, in the developmental changes of K+ currents in cultured neonatal rat ventricular cells." European Journal of Physiology. 434. 206-208 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NISHIYAMA Atsushi, KAMBE Fukushi, KAMIYA Kaichiro, YAMAGUCHI Shunsuke, MURATA Yoshiharu, SEO Hisao, TOYAMA Junji: "Effects of thyroid and glucocorticoid hormones on Kv1.5 potassium channel gene expression in the rat left ventricle." Biochemical and Biophysical Research Communications. 237. 521-526 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] LEE Jong-Kook, KODAMA Itsuo, HONJO Haruo, ANNO Takafumi, KAMIYA Kaichiro, TOYAMA Junji: "Stage-dependent changes in membrane currents inrats with monocrotaline-induced right ventricular hypertrophy." American Journal of Physiology. 272(Heart and Circulatory Physiology 41). H2833-H2842 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KAMIYA Kaichiro, GUO Weinong, TOYAMA Junji: "Modulation of potassium channels by chronic hypoxia in neonatal rat cultured ventricular myocytes." Environmental medicine. 41(1). 60-62 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NISHIYAMA Atsushi, KAMBE Fukushi, KAMIYA Kaichiro, SEO Hisao, TOYAMA Junji: "Effect of thyroid hormone on the expression of Kv4.2 and Kv4.3 potassium channel genes in the rat heart." Environmental Medicine. 41(2). 117-119 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] CHENG Jianhua, KAMIYA Kaichiro, TOYAMA Junji: "Regional difference in the delayd rectifier K+ current components (Ikr and IKs) in myocytes isolated from the apical and basal regions of rabbit ventricle." Environmental Medicine. 41(1). 65-67 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] LIU Weiran, YASUI Kenji, ARAI Akiko, KAMIYA Kaichiro, TOYAMA Junji: "L-type calcium channel current in the embryonic mouse heart." Environmental Medicine. 41(1). 70-71 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, YASUI Kenji, KODAMA Itsuo, TOYAMA Junji: "alpha_1-Adrenoceptor agonists and IGF-1, myocardial hypertrophic factors, regulate the Kv1.5 K^- channel expression differentially in cultured newborn rat ventricular cells." Pflugers Archives-European Journal of Physiology. 436. 26-32 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, KODAMA Itsuo, TOYAMA Junji: "Cell cycle-related changes in the voltage-gated Ca^<2+> currents in cultured newborn rat ventricular myocytes." Journal of Molecular and Cellular Cardiology. 30. 1095-1103 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, KADA Kenji, KODAMA Itsuo, TOYAMA Junji: "Regulation of cardiac Kv1.5 K^+ channel expression by cardiac fibroblasts and mechanicala load in cultured newborn rat ventricular myocytes." Journal of Molecular and Cellular Cardiology. 30. 157-166 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] GUO Weinong, KAMIYA Kaichiro, HOJO Mayumi, KODAMA Itsuo, TOYAMA Junji: "Regulation of Kv4.2 and Kv1.4 K^+ channel expression by myocardial hypertrophic factors in cultured newborn rat ventricular cells." Journal of Cellular and Molecular Cardiology. 30. 1449-1455 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NISHIYAMA Atsushi, KAMBE Fukushi, KAMIYA Kaichiro, SEO Hisao, TOYAMA Junji: "Effects of thyroid status on expression of voltage-gated potassium channels." Cardiovascular Research. 40. 343-351 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KAMIYA Kaichiro, YOSHIDA Shuichiro, HOJO Mayumi, YASUI Kenji, KODAMA Itsuo: "Acute effects of amiodarone on E-4031-sensitive (I_<Kr>) and 293B-sensitive (I_<Ks>) components of delayd rectifire potassium channels in rabbit ventricular myocytes." Environmental Medicine. 42. 128-130 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TAKEUCHI Susumu, NISHIYAMA Atsushi, KAMIYA Kaichiro, KAMBE Fukushi, SEO Hisao, TOYAMA Junji, KODAMA Itsuo: "Chronic effects of amiodarone on gene expression of Kv4.2 K^- channel subunit in the rat heart." Environmental Medicine. 42. 131-133 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kamiya K., YOSHIDA S., HOJO M.et al.: "Acute effects of amiodarone on E-4031-sensitive (I_<Ks>) and 293B-sensitive (I_<Ks>) components of delayed rectifier potassium channels in rabbit ventricular myocytes." Environmental Medicine. 42. 128-130 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] HISHIYAMA A., KAMBE F., KAMIYA K., et al.: "Effects of thyroid status on expression of voltage-gated potassium channels." Cardiovascular Research. 40. 343-351 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] GUO W., KAMIYA K., HOJO M., et al.: "Regulation of Kv4.2 and Kv1.4 K^+ channel expression by myocardial hypertrophic factors in cultured newborn rat ventricular cellss." Journal of Molecular Cellular Cardiology. 30. 1449-1455 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] GUO W., KAMIYA K., KADA K., et al.: "Regulation of cardiac Kv1.5 K^+ channel expression by cardiac fibroblasts and mechanical load in cultured newborn rat ventricular myocytes." Journal of Molecular Cellular Cardiology. 30. 157-166 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] GUO W., KAMIYA K., KODAMA I., et al.: "Cell cycle-related changes in the voltage-gated Ca^<2+> currents in cultured newborn rat ventricular myocytes." Journal of Molecular Cellular Cardiology. 30. 1095-1103 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] GUO W., KAMIYA K., YASUI K., et al.: "α_1-Adrenoceptor agonists and IGF-1, myicardial hypertrophic factors, regulate the Kv1.5 K^+ channel expression differentially in cultured newborn rat ventricular cells." European Journal of Physiology. 436. 26-32 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] NISHIYAMA Atsushi,KAMBE Fukushi,KAMIYA Kaichiro,YAMAGUCHI Shunsuke,MURATA Yoshiharu,SEO Hisao,TOYAMA Junji:"Effects of thyroid and glucocorticoid hormones on Kv1.5 otassium channel gene expression in the rat left ventricle." Biochemical and Biophysical Research Communications. 237. 521-526 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] NISHIYAMA Atsushi,KAMBE Fukushi,KAMIYA Kaichiro,SEO Hisao,TOYAMA Junji:"Effects of thyroid hormone on the expression of Kv4.2 and Kv 4.3 potassium channel genes in the rat heart." Environmental Medicine. 41.2. 117-119 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] GUO Weinong,KAMIYA Kaichiro,TOYAMA Junji:"Evidences of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes." Journal of Mollecular Cellular Cardiology. 29. 617-627 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 神谷香一郎,児玉逸雄: "循環器疾患I,II分子生物学 病態と心筋イオンチャネル発現の修飾." 最新内科学体系 プログレスシリーズ. 72-81 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 神谷香一郎,外山淳治: "不整脈の電気生理学的機序." 「抗不整脈薬のすべて」Part2基礎編. 49-93 (1997)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi