| Project/Area Number |
09670718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
BEPPU Shintaro Osaka Univ.Med.School Professor, 医学部, 教授 (40113500)
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| Co-Investigator(Kenkyū-buntansha) |
MASUYAMA Toru Osaka Univ.Med.School Assistant Professor, 医学部, 助手 (70273670)
ISHIKURA Fuminobu Osaka Univ.Med.School Assistant Professor, 医学部, 助手 (50303970)
HORI Masatsugu Osaka Univ.Med.School Professor, 医学部, 教授 (20124779)
近藤 寛也 大阪大学, 医学部, 助手 (40294102)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Ultrasound / Ischemic Heart Disease / Circulation / Contrast / Perfusion |
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| Research Abstract |
The echocardiography is an indispensable tool for diagnosing ischemic heart disease.So far, echocardiography provides important and useful information such as wall motion abnormalities, cardiac function, anatomical and functional complications etc due to myocardial infarction.
Nevertheless, myocardial perfusion has not been elucidated using echocardiography.Myocardial contrast echocardiography is a promising tool ; especially intravenous method is available.In this research, we examined the feasibility of myocardial contrast echocardiography for detecting coronary obstruction and stenosis in canines using intracoronary injection method.The area at risk covered by stenotic coronary artery was not opacified using combination with vasodilating agent, while the myocardium was well opacified despite coronary stenosis without vasodilating agent.Consequently, we examined the efficacy of intravenous myocardial contrast echocardiography.The ultrasonic contrast agent opacified myocardium well even via venous injection.The combination use of second harmonic imaging was extremely useful for visualizing myocardial opacification clearly and reducing the dose of contrast agent.The experimental setup was almost same as that for the intracoronary injection method.The myocardium was clearly opacified and the low perfused area was not opacified.The contrast of videointensity between was definite and leads the conclusion that the intravenous myocardial contrast echocardiography is useful for diagnosing ischemic heart disease.
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