| Project/Area Number |
09670724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | KYUSHU UNIVERSITY FACULTY OF MEDICINE |
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Principal Investigator |
TSUTSUI Hiroyuki KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ADJUNCT ASSISTANT PROFESSOR, 医学部, 講師 (70264017)
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| Co-Investigator(Kenkyū-buntansha) |
TAGAWA Hirofumi KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (60304797)
OHARA Yuichi KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (90185364)
EGASHIRA Kensuke KYUSHU UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (60260379)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Heart failure / Nitric oxide / Myocyte / Contractility / beta-adrenergic receptor |
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| Research Abstract |
Heart failure is associated with the contractile dysfunction and theimpaired responsiveness to beta-adrenergic stimulation at the myocyte level of unknown causes. Heart failure increased nitric oxide (NO) in the myocardium, which was responsible for the diminished contractile responses to beta-adrenergic stimulation. The association of NO and contractile abnormalities was recognized in the animal model of failing heart and increased NO induction might have pathophysiological significance for the contractile defects in congestive heart failure.
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