| Project/Area Number |
09670745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
NASU Masataka Iwate Medical University.Dpt of Medicine.Assistant professor, 医学部, 講師 (20180531)
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| Co-Investigator(Kenkyū-buntansha) |
KURIKI Satoshi Iwate Medical University.Dpt of Medicine.Assistant professor, 医学部, 助手 (50285631)
YASHIMA Nobuhiro Iwate Medical University.Dpt of Medicine.Assistant professor, 医学部, 助手 (00285587)
FUKAMI Kenichi Iwate Medical University.Dpt of Medicine.Associate professor, 医学部, 助教授 (90238444)
TASHIRO Atsushi Iwate Medical University.Dpt of Medicine.Assistant professor, 医学部, 助手 (60227072)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Transthoracic Doppler echocardiography / Coronary blood flow / Coronary artery stenosis / Coronary blood flow reserve / 経胸壁ドプラ心エコー図法 |
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| Research Abstract |
Although it was. difficult to visualize epicardia1 coronary artery blood by transthoracic echocardiography, recent development of ultrasound instrument enable to visualize epicardial artery flow. We investigated the detection rate oLthe coronary artery blood flow and studied the diagnostic efficacy of coronary artery stenosis by transthoracic Doppler echocardiography using Sequoia system.
The highly sensitive color and pulsed Doppler echo allowed efficient detection not only of the left anterior descending coronary artery (LAD), but also the proximal portion of the left circumflex artery. It was found that the coronary blood flow reserve (CFR) of LAD measured by transthoracic Doppler echocardiography was comparable in accuracy with CFR measured by invasive methods (r=0.87, p<0.0001).
Coronary flow mapping in LAD was performed by the color Doppler-guided pulsed Doppler and diastolic mean velocity ratio (DMVR) in LAD was calculated from highest diastolic mean velocity (HDMV) and lowest diastolic mean velocity (LDMV) (DMVR = HDMV/ LDMV). When DMVR was 2.0 or more which was regarded as an abnormally high value, stenotic lesion with 50% diameter stenosis (DS) or more DS was diagnosed with 93% sensitivity and 93 % specificity.
The good collateral coronary blood flow through the septal branches from right coronary artery to LAD was visualized by transthoracic color Doppler echocardiography.
Highly sensitive transthoracic Doppler echocardiography was very useful to evaluate non.invasively and accurately coronary stenosis.
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