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Chronomes (rhythms, chaos and disease and age trends) of heart rate variability in patients with coronary artery disease (CAD)

Research Project

Project/Area Number 09670760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

OTSUKA Kuniaki  Tokyo Women's Medical University, School of Medicine, Professor, 医学部, 教授 (60038908)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Keywordschronome / autonomic nervous activity / heart rate variability / rhythms / trends / fractal / chaos / complexity / カオス / 複雑性 / クロノス
Research Abstract

Heart rate variability (HRV) may reflect autonomic nervous activity. From 24-hour Holter ECG records on 66 male patients with CAD 30-88 years of age as well as on 339 healthy subjects (222M, 117F), 3-92 years of age, time-and frequency-domain and chaotic measures (correlation demension, CD, and complexity) of HRV were computed. Contrary to the results in health where most variables were found to statistically decrease with age, in the patients with CAD, only LF and CD decreased with age with statistical significance. The patients with CAD are found to differ from clinically healthy men of similar age in terms of SDNN, SDANN, TF, LF, LF/HF and CD.An assessment of chronomes of HRV may contribute to the diagnosis, prognosis and as putative guides to treatment timing.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Kuniaki Otsuka: "Vagal tone and various assessments of complexity of heart rate variability in healthy Japanese subjects." Therapeutic Research. 19・2. 265-275 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 大塚邦明: "時間生物学的アプローチ" 循環器専門医. 6・1. 69-73 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 大塚邦明: "循環器とサーカディアンリズム" 自律神経. 35・3. 271-279 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuniaki Otsuka: "Weekly variation of time domain measures of heart rate variability and geomagnetics in Asian Chronome Ecological Study of heart rate variability." Therapeutic Research. 20・2. 388-395 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 大塚邦明: "心拍変動の臨床応用 III, 狭心症・虚血性心疾患と心拍変動" 医学書院, 37-60 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuniaki OTSUKA et al.: "Vagal tone and various assessments of complexity of heart rate variability in healthy Japanese subjects." Therapeutic Research. 19(2). 265-275 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuniaki OTSUKA et al.: "From homeostasis to chronobiology." JUNKANKI-SENMON-I. 6(1). 69-73 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuniaki OTSUKA et al.: "Chronos and chaos : heart rate variability in healthy Japanese." Autonomic Nervous System. 35(3). 271-279 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuniaki OTSUKA et al.: "Weekly variation of time domain measures of heart rate variability and geomagnetics in Asian Chronome Ecological Study of heart rate variability (ACEHRV)." Therapeutic Research. 20(2). 388-395 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KuniaKi OTSUKA et al.: "Effort angina, ischemic heart disease and heart rate variability" Clinical Application of Heart Rate Variability, Hayashi H eds.Igaku-Shoin. 37-60 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuniaki Otsuka: "Vagal tone and various assessments of complexity of heart rate variability in healthy Japanese subjects." Jherapeutic Research. 19・2. 265-275 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大塚邦明: "時間生物学的アプローチ" 循環器専門医. 6・1. 69-73 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大塚邦明: "循環器とサーカディアンリズム" 自律神経. 35・3. 271-279 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuniaki Otsuka: "Weekly variation of time domain measures of heart rate variability and geomagnetics in Asian Chronome Ecological Study of heart rate variability." Therapeutic Research. 20・2. 388-395 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大塚邦明: "心拍変動の臨床応用 III.狭心症・虚血性心疾患と心拍変動" 医学書院, 37-60 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuniaki OTSUKA: "Vogal tone and various assessments of complexity of heart rate variability in healthy Japanese subjeds" Therapeutic Research. 19(2). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大塚邦明: "非侵襲的診断法 3, 時間生物学的アプローチ" 循環器専門医. 6(1). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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