| Project/Area Number |
09670766
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | St.Marianna University School of Medicine |
|---|
Principal Investigator |
TANABE Kazuhiko St.Marianna University School of Medicine, The Medical Department, Lectures, 医学部, 講師 (70197507)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | Erythrocyte magnesium / Nitric oxide / Sleep deprivation / Exercise tolerance / Magnesium administration / Noradrenaline |
|---|
| Research Abstract |
Our previous study have shown that chronic sleep deprivation caused deficiency of intracellular magnesium (Mg) concentration, and it may contribute to coronary artery spasm. The present study is designed to clarify the relationship between nitric oxide (NO), as endothelial relaxation factor and intracellular Mg concentration. The subjects were 10 healthy volunteers. The study conditions were designed as follows (A) sleep deprivation state with duration of sleep less than 60% of control state for 1 month, (B) a day following a night good of sleep of as the control state. Intracellular Mg and NO were measured in each state.
The results were as follows : (1) Plasma NO level was higher in 7 out of 10 subjects during sleep deprivation state than those in control. On the other hand, the remaining plasma NO level was lower. (2) Serum Mg level was similar in both states (1.9 * 0.1 at control state vs 2.0 * 0.1 mg/dl at sleep deprivation). The mean intracellular Mg concentration was less in the state of chronic sleep deprivation (2.7 * 0.7 vs 2.0 * 0.4 mg/dl). (3) There was significantly inverse correlation between plasma NO and intracellular Mg concentration (r=-0.49, p(]SY.di-substituted right.[)O.O5), but no correlation between serum Mg and plasma NO.
Our findings suggest that NO level may be responsive to changes in intracellular Mg and increase of plasma NO level may compensate the defficiency of intracellular Mg which can cause arterial spasm.
|
