| Project/Area Number |
09670783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | TSUKUBA UNIVERSITY |
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Principal Investigator |
SHIBASAKI Masanao UNIVERSITY OF TSUKUBA,INSTITUTE OF CLIN.MED., ASSOCLATE PROFESSOR., 臨床医学系, 助教授 (30049233)
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| Co-Investigator(Kenkyū-buntansha) |
ARINAMI Tadao UNIVERSITY OF TSUKUBA,INSTITUTE OF BASIC.MED., ASOCLATE PROFESSOR., 基礎医学系, 助教授 (10212648)
HAMAGUCHI Hideo UNIVERSITY OF TSUKUBA,INSTITUTE OF BASIC.MED., PROFESSOR., 基礎医学系, 教授 (00091918)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Allupy / Asthma / atopy / gene / 5q31-33 / 羅患同胞対法 / gene / IgE / 連鎖 / 喘息 / T細胞レセプター |
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| Research Abstract |
SusceptibiIity to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy and asthma. We have examined a linkage between traits of specific IgE responses to the house dust mite and its purified aller- gens, high total serum IgE levels and asthma, and the markers at the T-cell receptor (TCR) alpha chain gene (TCR-alpha) and beta chain gene (TCR-beta) in Japanese families ascertained through asthmatic children. Affected sib- pair analyses provided evidence for linkage between TCR-beta and nearby markers (D7S684) on chromosome 7q35 and both IgE and asthmatic phenotypes, but no evidence for linkage of IgE responses nor asthma phe- notype to TCR-alpha was detected The results suggest the presence of major gene(s) controlling atopy and asthma susceptibility in TCR-beta and the nearby region.
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