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Electrophysiological evaluation of the higher brain dysfunction in children with epilepsy

Research Project

Project/Area Number 09670789
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

KONISHI Tohru  Toyama Medical and Pharmaceutical University, Pediatrics, Associate Prof., 医学部, 助教授 (30115167)

Co-Investigator(Kenkyū-buntansha) YAGI Shinichi  Toyama Medical and Pharmaceutical University, Pediatrics, Assistant Professor, 医学部, 助手 (30182299)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordschildhood / epilepsy / higher brain dysfunction / cognitive function / maturation / electroencephalography / power spectrum / event-related potential / 年齢発達 / Epilepsy / Electroencephalography / Power spectrum / Event-related potential / Cognitive bunction
Research Abstract

The onset and clinical course of childhood epilepsy generally showed age-dependency, so may be related to the CNS maturation. Contrary, disadvantage factors associated with epilepsy may affect to the CNS maturation, In this study, we studied the higer bain dysfunction in children with epilepsy using electrophysiological methods : 1) power-spectral analysis of BEG background activity for an indicator of whole brain neuronal activity, and 2) event-related potential (P300) for an indicator of cognitive function.
The longitudinal evaluation was done in 150 children with epilepsy, being compared with those in 50 normal children. Results were as follows : 1) Significant slowing of background activity and prolongation of P300 latency were widely observed in children with epilepsy. 2) The degree and age- change of these abnormalities were quite different between each epileptic syndrome. it indicates that the higher brain dysfunction mainly depended on epileptogenesis itself. 3) The dysfunction was more prominent during active phase of epilepsy, and became to be lesser after seizure control. 4) The direct effect of seizure occurrence was a littel, but the dysfunction tended to be related to the long-term seizure prognosis. 5) The effect of anticonvulsant therapy was transient at early phase of therapy, but being a little during chronic medication.
Our results suggest that some minimaI higher brain dysfunction generally combined in children with epilepsy, even if being no distinct retardation. These dysfunction may be originated from epileptogenesis itself. Preventive education or habitation programs from ealy phase of therapy is necessary for comprehensive therapy of epilepsy.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Naganuma Y.: "Event-related potential(P300)and EEG activity in childhood portial epilepsy." Brain & Development. 19・2. 117-121 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naganuma Y.: "Epileptic seiqures and event-related potentials(P300)in childhood partial epilepsy." Clinical EEG. 28・2. 106-110 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naganura Y.: "Event-related potentials (P300) and EEG activity in childhood partial epilepsy" Brain & Developmant. 19-2. 117-121 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naganura Y.: "Epileptic seizures and event-related potentials (P00) in childhood partial epilepsy" Clinical EEG. 28-2. 106-110 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naganuma Y.et al.: "Epileptic seizures and event-relafed patentials(P300)in childhood partial epilepsies." Clinical Electroencephalography. 28・2. 106-111 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Naganuma Y,et al.: "Event-related potentials(p300)and EEG actioily in childhood particalepilepsy." Brain & Development. 19・2. 117-121 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小西 徹: "てんかんの最新診断法・検査法" 治療. 79・9. 1993-1999 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Naganuma Y.et.al.: "Event-related potential(P300)and EEG activity in childhood partial epilepsy." Brain & Development. 19(2). 117-121 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naganuma Y.et.al: "Epileptic seizures and event-related potential(P300)in childhood partial epilepsy." Clinical Electroencephalography. 28(2). 106-111 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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