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Experimental study on pathogenesis of cortical dysplasias

Research Project

Project/Area Number 09670799
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionShiga University of Medical Science

Principal Investigator

SHIMADA Morimi  Shiga University of Medical Science, School of Medicine, Pediatrics, Professor, 医学部, 教授 (00079873)

Co-Investigator(Kenkyū-buntansha) TAKANO Tomoyuki  Shiga University of Medical Science, School of Medicine, Pediatrics, Assistant P, 医学部, 助手 (80236249)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordscortical dysplasia / hydrocephalus / plymicrogyria / mumps virus / hypoxic ischemic encephalopathy / plasticity / サイトシンアラビノシド / ムンプス ウイルス / 上衣細胞
Research Abstract

Pathogenesis of congenital hydrocephalus and polymicrogyria was investigated using model animals which were produced experimentally either by inoculating mumps virus, placing in an hypoxic/ischemic condition or by regional resection of the cortex.
1) Pathogenesis of hydrocephalus : Two groups of Syrian hamsters, either 2- or 30-day-old, were inoculated intracerebrally with 20 ul/g brain of mumps virus. These animals from each group were examined at various days after inoculation. in a group inoculated with mumps virus at 2 days of age, pathologic findings such as periventricular edema, ependymal cell loss, and ventricular dilatation were more prominent than in a group inoculated at 30 days of age. ZO1-immunoreactive tight junctions in hydrocephalic brain of the 2-day group were severely damaged in the choroid plexus and ependyma, and in white matter capillaries as early as 3 days after inoculation. These changes were not apparent in the hydrocephalic brains of the 30-day group. Periventricular edema in the 2-day group was linked to ependymal and blood-brain barrier tight-junction permeability. These results indicate that immaturity and fragility of the tight junction in the developing brain may play a role for cortical dysplasia after the exposure of noxious environmental factors.
2) Pathogenesis of polymicrogyria : Hypoxic/ischemic model was produced by ligating the left common carotid artery of newborn rat and then placed them in hypoxic condition for 2 h. The animals thus treated subsequently developed policystic lesion and/or polymicrogyric changes in the cerebral cortex. In the early stage of treatment, a tentative increase of full-length TrkB receptors and basic fibroblast growth factor (bFGF) in neuron in the former and in astrocyte in the latter around the lesion and related regions. These results indicate that the regional increase in neurotophic factors and neuronal plasticity after damage play an important role for later maldevelopment of the cortex.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Masaaki Uno: "Age-dependent susceptibility in mumps-associated hydrocephalus : neuropathologic features and brain barriers." Acta Ncuropathologica. 94. 207-215 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaki Ohno: "Multiple abnormal magnetic resonance imaging signals in a patient with minimal neurological symptoms." European Journal of Paediatric Neurology. 1. 39-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Seiro Narumiya: "Enhanced expression of full-length TrkB receptors in young rat brain wity hypoxic/ischemic injury." Brain Research. 797. 278-286 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akira Aisaka: "Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters." Neuroscience. 90. 53-67 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naoto Tanaka: "Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury." Brain Research. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 島田 司巳: "神経細胞の生成・移動障害-発生病理と臨床-" 小児科. 38(11). 1353-1360 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaaki Uno: "Tight junctional damage in experimental mumps associated hydrocephalus." Congenital Anomalies. 37. 157-163 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaaki Uno: "Age-dependent susceptibility in mumps-associated hydrocephalus : neuropathologic features and brain barriers." Acta Neuropathologica. 94. 207-215 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaki Ohno: "Multiple abnormal magnetic resonance imaging signals in a patient with minimal neurological symptoms." European Journal of Paediatric Neurology. 1. 39-40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Eiji Nakagawa: "Efficacy of pyridoxal phosphate in treating an adult with intractable status epileptics." Neurology. 48. 1468-1469 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Seiro Narumiya: "Enhanced expression of full-length TrkB receptors in young rat brain with hypoxic/ischemic injury." Brain Research. 797. 278-286 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akira Aisaka: "Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters." Neuroscience. 90. 53-67 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Naoto Tanaka: "Heparin-binding epidermal growth factor-like growth mRNA expression in neonatal rat brain with hypoxic/ischemic injury." Brain Research. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomoyuki Takano: Experimental study on pathogenesis of brain lesions in hamsters following intraplacental inoculation with mumps virus.New Developments in Child Neurology. ed.by Milivoj Velickovic. Monduzzi Editore, Bologna Italy, 389-392 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaki Uno: "Age-dependent susceptiobility in mumps-associated hydrocephalus: neuropathologic features and brain barriers." Acta Neuropathologica. 94. 207-215 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masaki Olmo: "Multiple abnormal magnetic resonance imaging signals in a patient with minimal neurological symptoms." European Journal of Paediatric Neurology. 1. 39-40 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Seiro Narumiya: "Enhanced expression of full-length TrkB receptors in young rat brain with hypoxic/ischemic injury." Brain Research. 797. 278-286 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akira Aisaka: "Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters." Neuroscience. 90. 53-67 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Naoto Tanaka: "Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury." Brain Research. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 島田 司巳: "神経細胞の生成・移動障害-発生病理と臨床-" 小児科. 38(11). 1353-1360 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 島田司巳: "神経細胞の生成・移動障害-発生病理と臨床-" 小児科. 38. 1353-1360 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masaaki Uno: "Age-dependent susceptibility in mumps-associated bydrocephalus : neuropathologic features and brain barriers." Acta Neuropathologica. 94. 207-215 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masaak Uno: "Tight junctional damage in experimental mumps-associated bydrocephalus." Congenrtal Anomaly. 37. 157-163 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakagawa Eiji: "Efficacy of pyridotal phosphate in treating an adult with intractable status epilepticus." Neurology. 48. 1468-1469 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 島田司巳: "脳形成障害の発生病理の多様性" 脳と発達. 28・2. 93-101 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Junji Uematsu: "Development of corticospinal tract fibers and their plastierty.I : Quantitative analysis of developing corticospinal tract in micel" Brain & Development. 18・1. 29-34 (1996)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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