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Suppressive effects of adrenomedullin, a novel hypotensive peptide, on the progression of pulmonary hypertension

Research Project

Project/Area Number 09670803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

YOSHIBAYASHI Muneo  Kyoto University, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (80273449)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsadrenomedullin / pulmonary hypertension / congenital heart disease / モノクロタリン
Research Abstract

1. Four-week-old male Wistar rats (n=20) were given a subcutaneous injection of 60 mg/kg monocrotaline. Since then, rat adrenomedullin (AM) of 5 mug/day was administered subcutaneously for 3 weeks to the half of them (PH-AM group ; n=10), and 0.9% saline in the same way to the other half (PH-saline group ; n=10). After the administration for 3 weeks, right ventricular systolic pressure (RVP) was measured with a catheter inserted through the right jugular vein and blood was collected from the catheter. The plasma AM concentration was measured using the radioimmunoassay from the sample. Then the rat was sacrificed and the ratio of right ventricular weight to body weight (RV/BW) and the ratio of medial thickness to external diameter of the pulmonary artery (%MT) were measured. The plasma AM concentration in the PH-AM group was significantly elevated than that in the PH-saline group. RVP, RV/BW and %MT in the PH-AM group were significantly lower than those in the PH-saline group. These results indicate that AM suppresses the progression of pulmonary hypertension in rats treated with monocrotaline.
2. Plasma AM concentrations were measured in pediatric patients with cardiovascular diseases. Plasma AM concentrations were elevatcd in patients with pulmonary hypertension and in those with congenital cyanotic heart disease, suggesting that adrenomedullin may be involved in cardiovascular regulation in these diseases.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 吉林 宗夫: "新しい血管拡張ペプチド、アドレノメデュリンの肺高血圧治療薬としての可能性" 日本小児循環器学会雑誌. 14. 178 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muneo Yoshibayashi: "Plasma Levels of Adrenomedullin in Primary and Secondary Pulmonary Hypertension in Patients < 20 Years of Age" American Journal of Cardiology. 79. 1556-1558 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muneo Yoshibayashi: "Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease" Clinical Science. 96 印刷中. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muneo Yoshibayashi: "Adrenomedullin as a possible therapeutic agent for pulmonary hypertension." Acta Cardiologica Paediatrica Japonica. 14. 178 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muneo Yoshibayashi: "Plasma levels of adrenomedullin in primary and secondary pulmonary hypertension in patients <20 years of age." American Journal of Cardiology. 79. 1556-1558 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muneo Yoshibayashi: "Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease." Clinical Science. 96 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1997-04-01   Modified: 2016-04-21  

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