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Effect of intense sports activity on carnitine metabolism in youth and children

Research Project

Project/Area Number 09670804
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKYOTO UNIVERSITY OF EDUCATION

Principal Investigator

INOUE Fumio  Department of Physical Education, Kyoto University of Education, Professor, 教育学部, 教授 (40168464)

Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsSPORTS / CARNITINE / BUTYROBETAINE / TRIMETHYLLYSINE / PIVALIC ACID / カルニテン
Research Abstract

Background : Carnitine plays an important role in fatty acid oxidation, that is one of main energy sourses of muscles during aerobic exercise. Recently, several drugs (some of antibiotics, anticonvulsants, antineoplastics) have been reported to cause carnitine deficiency. Children and youth, who participate in intense regular exercise, may have an opportunity to take these drugs.
Objective : To study the effects of intense physical activity on carnitine metabolism in youth and children.
Methods : Carnitine and its precursors were analyzes by tandem mass spectrometry.
Results : Analytical methods for free carnitne, acylcarnitines, butyrobetaine, trimethyllysine were established by tandem mass spectrometry in secondary ion mass spectrometric mode, that enabled us to conduct the study of physical exercise because of a small amount of sample volume required. Sports activity caused increased serum levels of butyrobetaine, acetylcarnitine, C4-and C8-acylcarnitines and decreased serum levels of free carnitine. Administration of pivalate-containing antibiotic caused decreased serum levels of free carnitne and increased serum CK and myoglobin.
Conclusion : Carnitine deficiency induced by drug administration may cause impaired fatty acid oxidation and metabolic damage of muscular tissue.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Inoue F et al.: "Effect of sports activity carnitine metabolism -Measurement of free carnitine,γ- butyrobetaine and acylcarnitines by tandem mass spectrometry-"Journal of Cromatography B. 731. 83-88 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada N et al.: "Measurement of carnitine precursors, ε-trimethyllysine and butyrobetaine In human serum by tandem mass spectrometry"Journal of Cromatography B. 731. 89-95 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajim H et al.: "Carnitine import to isolated hepatocytes and syntesis are accerelated in pivalate-treated rats"Journal of Nutrition. 129. 1688-1691 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishimura Y et al.: "Anomaly of chromosome 18 complicated with diabetes mellitus and hyperthyroidism"Pediatrics International. 41. 177-180 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshino M et al.: "Management of acute metabolic decompensation in maple syrup urine disease : a multi-center study"Pediatrics International. 41. 132-137 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujitake J et: "L-2-hydroxy glutaric aciduria : two Japanese adult cases in one"Journal of Neurology. 246. 378-382 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajima T et al.: "The effect of camitine on ketogenesis in perfused livers from Juvenile visceral steatosis mice with systemic camitine deficiency"Pediatric Research. 42. 108-113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue F et al.: "Analysis of dried blood spots by electro-spray mass spectrometry (in Japanese)"Bulletin of Kyoto University of Education B. 91. 1522 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada N et al.: "Trimethyllysine analysis by liquid SIMS/MS : Interference by homoarginine (in Japanese)"Proceedings of the Japanese Society for Biomedical Mass Spectrometry. 23. 165-168 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue F et al.: "Effect of sports activity on camitine metabolism (in Japanese)"Proceedings of the Japanese Society for Biomedical Mass Spectrometry. 23. 169-172 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue F et al.: "Effect of sports activity on camitine metabolism-Measurement of free camitine, g-butyrobetaine and acylcamitines by tandem mass spectrometry-"Joumal of Chromatography B. 731. 83-88 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada N et al.: "Measurement of camitine precursors, e-trimethyllysine and butyrobetaine in human serum by tandem mass spectrometry"Joumal of Chromatography B. 731. 89-95 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajim H et al.: "Camitine import to isolated hepatocytes and syntesis are accerelated in pivalate-treated rats"Joumal of Nutrition. 129. 1688-1691 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishimura Y et al.: "Anomaly of chromosome 18 complicated with diabetes mellitus and hyperthyroidism"Pediatrics Intemational. 41. 177-180 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshino M et al.: "Management of acute metabolic decompensation in maple syrup urine disease : a multi-center study"Pediatrics Intemational. 41. 132-137 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujitake J et al.: "L-2-hydroxyglutaric aciduria : two Japanese adult cases in one family"Joumal of Neurology. 246. 378-382 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue, F.et al: "Effect of sports activity on carnitine metabolism.Measurement of free carnitine,γ-butyrobetaine and acylcarnitines by tandem mass spectrometry"J Chromatogr. B731. 83-88 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Terada, N.et al: "Measurement of carnitine precursors,ε-trimethylbutyrobetaine in human serum by tandem mass spectrometry"J Chromatogr. B731. 89-95 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakajima, H.et al: "Carnitine import to isolated hepatocytes and synthesis are accelerated in pivalate-treated rats"J Nutr. 129. 1688-1691 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujitake, J.et al: "L-2-Hydroxyglutaric aciduria: two Japanese adult cases in one family"J Neurol. 246. 378-382 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishimura, Y.et al: "Anomaly of chromosome 18 complicated with diabetes mellitus and hyperthyroidism"Pediatr Int. 41. 177-180 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 井上文夫: "スポーツ活動がカルニチン代謝に及ぼす影響" 日本医用マススペクトル学会講演集. 23. 169-172 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 寺田直人: "Liquid SIMSによるtrimethyllysine測定の再検討-homoarginineによる妨害について-" 日本医用マススペクトル学会講演集. 23. 165-168 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 村田美由紀: "ビオチン欠乏が原因と考えられた3-メチルクロトニルグリシン尿症の1乳児例" 小児科臨床. 51. 449-453 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井上文夫: "本学健康診断での体脂肪測定の有用性の検討" 京都教育大学紀要. 93. 1-12 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 井上文夫: "エレクトロスプレーマススペクトロメトリーによる濾紙血の分析" 京都教育大学紀要. 91. 15-21 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakasima,Toshihiro: "The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency" Pediatric Research. 42(1). 108-113 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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