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Studies of eraly and prenatal diagnosis of congenital cytomegalovirus infection

Research Project

Project/Area Number 09670822
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionSapporo Medical University

Principal Investigator

NUMAZAKI Kei  Sapporo Medical University, School of Medicine, Department of Pediatrics, Assistant Professor, 医学部, 講師 (00228272)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Keywordscytomegalovirus (CMV) / congenital infection / cytokines / prenatal diagnosis
Research Abstract

We have studied the incidence of congenital cytomegalovirus (CMV) infection in Japan.
Currently, out of 7,995 neonates, 31 (0.39%) were identified as having congenital infection on the basis of viruria at birth. Three of 31 infected infants were symptomatic and died from generalized infection. The remaining 28 infants were all asymptomatic and showed no developmental abnormality nor sensorineural hearing loss. Maternal serum samples at 10 and 22 weeks of gestational age were available from six cases of congenital CMV infection.
Serum levels of cell free soluble interleukin-2 receptor (sIL-2R) and interferon (IFN)-gamma of 6 pregnant women were determined by ELISA.Serum activities of IL-4 and tumor necrosis factor (TNF)-alpha were not detected. IgG antibody to CMV was detected from all 6 women and IgM antibody was detected from one. Meaningful rise of serum IgG-antibody titers was occurred in three cases. Serum IFN-gamma activities were detected from all 6 cases. Serum cell free sIL-2R activity rose than normal range in one IgG and IgM antibody-positive and three IgG antibody-positive woman. It is likely that serum levels of cytokines such as sIL-2R and IFN-gamma are related to the reactivation of CMV during pregnancy. Assessment of the changes of serum cytokines in CMV antibody-positive pregnant women may be useful for the prenatal diagnosis of active CMV infection during pregnancy.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] Numazaki K,Asanuma H,Chiba S.: "Relationship between cytokines and human cytomegalovirus infection of breast milk." J.Infect.Chemother.3. 58-61. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K,Chiba S.: "Cytomegalovirus infection and restenosis." Stroke. 28. 1088-1090. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K.Ikehata M,Yanai S,Umetsu M,Motoya H,Chiba S.Sekine T.: "Adoptive immunotherapy for interstitial pneumonia associated with cytomegalovirus infection." Clin.Infec Dis.25. 1246-1247. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki,K.,Chiba,S.,Aoki,K.,Suzuki,K.,Ohno,S: "Human herpesvirus 8 variants." Lancet. 351. 679-680. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki,K.,Asanuma,H.,Ikehata,M.,Chiba,S.: "Detection of Cytokines and cytomegalovirus DNA in serum as test for congenital infection." Ear.Hum.Dev.52. 43-48. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki,K.,Ikehata,M.,Asanuma,H.,Chiba,S.: "Simultaneous infection of immunocompetent individuals with multiple cytomegalovirus strains." Lancet. 352. 1710. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 沼崎 啓.: "開業医のための性感染症-STD-" 東京,南山堂(印刷中), (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 沼崎 啓,千葉峻三.: "新女性医学大系,プライマリケア部門,第10巻 女性と感染症," 東京,中山書店, 458. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K.: "Human cytomegalovirus infection of brestmilk." FEMS Immunol. Med. Microbiol.18. 91-98 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Chiba, S.: "Current aspects of diagnosis and treatment of cytomegalovirus infections in infants." Clin.Diagn.Virol.8. 169-181 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Asanuma H, Chiba S.: "Relationship between cytokines and human cytomegalovirus infection of breast milk." J.Infect. Chemother.3. 58-61 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Niida Y, Chiba S.: "Antigen detection of Chlamydia trachomatis from the endocervix is not enough for screening of perinatal complications." Am.J.Obstet. Gynecol.176. 951-952 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Ikehata M, Chiba S.: "Role of cytomegalovirus in Menetrier disease in children." J.Pediatr.130. 681 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Chiba S.: "Cytomegalovirus infection and restenosis." Stroke. 28. 1088-1090 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Ikehata M, Chiba S, Aoki K.: "Reduction of trachoma in absence of a disease-control programme." Lancet. 350. 447-448 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K.: "Cytomegalovirus as pulmonary pathogen." Chest. 112. 860-861 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, chiba S, Aoki K, Suzuki K, Ohno S.: "Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis." Clin.Infect. Dis.25. 928-929 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Ikehata M, Yanai S, Umetsu M, Motoya H, Chiba S, Sekine T.: "Adoptive immunotherapy for interstitial pneumonia associated with cytomegalovirus infection." Clin.Infec Dis.25. 1246-1247 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Chiba S.: "Cytomegalovirus infection and Guillaine-Barre syndrome." Neurology. 49. 1472-1473 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Chiba, S.: "Chlamydia pneumoniae infection and coronary heart disease : Role of C.pneumoniae in pathogenesis of atherosclerosis must be determined." Brit.Med.J.315. 1538-1539 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sasajima, T., Hotsubo, T., Tomita, H., Numazaki, K., Nakata, S., Tsutsumi, H., Chiba, S.: "Precocious puberty during a treatment of prolonged hypothyroidism in a boy with Down syndrome : a case report." Clin.Pediatr.Endocrinol.6 (supplement 9). 125-128 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K: "Serological tests for Chlomydia trachomatis infections." Clin.Microbiol.Rev.11. 228-229 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K.: "CMV infection of the central nervous system." International Medical Journal (IMJ). 5. 251-153 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Chiba, S., Aoki, K., Suzuki, K., Ohno, S.: "Human herpesvirus 8 variants." Lancet. 351. 679-680 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Asanuma, H., Ikehata, M., Chiba, S.: "Detection of cytokines and cytomegalovirus DNA in serum as test for congenital infection." Ear.Hum.Dev.52. 43-48 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Ikehata, M., Akashi, E., Kusaka, T., Chiba, S.: "Seropositivity to Chlamydia trachomatis during pregnancy and perinatal complications." J.Infect. Chemother.4. 28-31 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Ikehata, M., Chiba, S., Suzuki, K., Hashimoto, N.: "Unclassified serovars of Chlamydia trachomatis isolated from Japanese infants." Clin.Microbiol. Infect.4. 519-523 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Niida, Y., Numazaki, K., Ikehata, M., Umetsu, M., Motoya, H., Chiba, S.: "Two fullterm infants with Chlamydia trachomatis pneumonia in the early neonatal period." Eur.J.Pediatr.157. 950-951 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki, K., Ikehata, M., Asanuma, H., Chiba, S.: "Simultaneous infection of immunocompetent individuals with multiple cytomegalovirus strains." Lancet. 352. 1710 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numazaki K, Asanuma H, Chiba S.: "Relationship between cytokines and human cytomegalovirus infection of breast milk." J.Infect.Chemother.3. 58-61 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numazaki K, Chiba S.: "Cytomegalovirus infection and restenosis." Stroke. 28. 1088-1090 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numazaki K, Ikehata M, Yanai S, Umetsu M, Motoya H, Chiba S. Sekine T.: "Adoptive immunotherapy for interstitial pneumonia associated with cytomegalovirus infection." Clin.Infec Dis.25. 1246-1247 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numazaki,K., Chiba,S., Aoki,K., Suzuki,K., Ohno,S: "Human herpesvirus 8 variants." Lancet. 351. 679-680 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numazaki,K., Asanuma,H., Ikehata,M., Chiba S.: "Detection of cytokines and cytomegalovirus DNA in serum as test for congenital infection." Ear.Hum.Dev.52. 43-48 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numazaki,K., Ikehata,M., Asanuma,H., Chiba,S.: "Simultaneous infection of immunocompetent individuals with multiple cytomegalovirus strains." Lancet. 352. 1710 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 沼崎 啓.: "開業医のための性感染症--STD--." 東京、南山堂(印刷中), (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 沼崎 啓、千葉峻三.: "新女性医学大系、プライマリケア部門、第10巻 女性と感染症、" 東京、中山書店(印刷中), (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numazaki K,Asanuma H,Chiba S.: "Relationship between cytokines and human cytomegalovirus infection of breast milk." J.Infect.Chemother.3. 58-61 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Numazaki K,Ikehata M,Chiba S.: "Role of cytomegalovirus in Menetrier disease in children." J.Pediatr.130. 681 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Numazaki K,Chiba S.: "Cytomegalovirus infection and restenosis." Stroke. 28. 1088-1090 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Numazaki K.: "Cytomegalovirus as pulmonary pathogen." Chest. 112. 860-861 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Numazaki K,Ikehata M,Yanai S,et al.: "Adoptive immunotherapy for interstitial pneumonia associated with cytomegalovirus infection." Clin.Infec Dis.25. 1246-1247 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Numazaki K,Chiba S.: "Cytomegalovirus infection and Guillaine-Barre syndrome." Neurology. 49. 1472-1473 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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