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Vertical transmission of HGV

Research Project

Project/Area Number 09670827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNagoya City University

Principal Investigator

SUGIYAMA Kohachiro  Nagoya City University, Medical, Lecturer, 医学部, 講師 (60117827)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsGBV-C / HGV / RT-PCR / Anti-E2 antibody / Gene Analysis / Vertical transmission / Child / 血清肝炎
Research Abstract

The transmission route of GBV-C/Hepatitis G virus (HGV) and the pathological role of this virus infection in liver disorder in children were investigated.
(1) The prevalence of HGV in pregnant Japanese women (aged 30.2 +/- 4.4 years) was 0.3% (1/288).
(2) The prevalence of HGV in children with no history of blood transfusion was 0.5% (5/1000). The mothers in all 5 families were positive, and among the 3 families two of the total 4 siblings were positive. Therefore, the prevalence of HGV in children born to HGV RNA-positive mothers was 78% (7/9). The mother in each case was positive for HGV and sequence homology analysis revealed no difference between child and their mothers, suggesting mother-to-infant transmission was the route of infection in these children.
(3) We detected HGV in 33.3% (11/33) and anti-E2 antibody in 3.7% (1/27) children in the malignant and 3 of 56 (5.4%) and 1.9% (1/53) children in the non-malignant groups. Neither HGV nor anti-E2 antibody was detected in the HBV and non A-C hepatitis groups. HGV and anti-E2 antibody were detected in 7 of 23 (30%) and 1 of 18 (5.6%) children in the HCV group. All these cases had a history of blood transfusion. The presence of HGV infection does not seem to be as critical as conventionally thought in association with childhood liver dysfunction.
(4) No anti-E2 antibody (0/330) was detected in children with no history of blood transfusion. This suggests that children infected with HGV became a carrier and the rate of seroconversion to anti-E2 antibody is low in childhood.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Goto K,Sugiyama K,et al.: "Prevalence of GB virus C/Hepatitis G virus ribonucleic acid and anti-hepatitis G virus-E2 antibodies among Japanese children with histories of transfusions or with liver diseases" Pediatric Research. 45・1. 128-132 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiyama K,Goto K,et al.: "Prevalence of GBV-C/HGV infection in pregnant Japanese women" Acta Paediatrica Japonica. 40・3. 385-386 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyake Y,Sugiyama K,et al.: "Using polymerase chain reaction to detect the etiological virus of serologically non-A, non-B, non-C fulminant hepatitis" Acta Paediatrica Japonica. 40・1. 102-104 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 杉山幸八郎,三宅能成,他: "輸血関連C型肝炎に重複感染したG型肝炎の小児例" 日本小児科学会雑誌. 100・12. 1923-1925 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Goto K, Sugiyama K, Li R, Miyake Y, Ando T, Mizutani F, Terabe K, Mizutani K, Wada Y: "Prevalence of GB virus C/Hepatitis G virus ribonucleic acid and anti-hepatitis G virus-E2 antibodies among Japanese children with histories of transfusions or with liver diseases." Pediatric Research. 45(1). 128-132 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiyama K, Goto K, Miyake Y, Mizutani F, Terabe K, Wada Y, Kajiura S: "Prevalence of GBV-C/HGV infection in pregnant Japanese women." Acta Paediatrica Japonica. 40. 385-386 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyake Y, Sugiyama K, Goto K, Ando T, Li R, Oda T, Mizutani F, Kawabe K, Wada Y: "Using polymerase chain reaction to detect the etiological virus of serologically non-A, non-B, non-C fulminant hepatitis." Acta Paediatrica Japonica. 40. 102-104 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiyama K, Miyake Y, Ando T, Oda T, Li R, Mizutani F, Maniwa H, Kawabe Y, Wada Y: "A child co-infected by hepatitis C and G associated with blood transfusion" The journal of the Japan pediatric society. 100(12). 1923-1925 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Goto K,Sugiyama K,et al.: "Prevalence of GB virus C/Hepatitis G virus ribonucleic acid and anti-hepatitis G virus-E2 antibodies among Japanese children with histories of transfusions or with liver diseases" Pediatric Research. 45・1. 128-132 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sugiyama K,Goto K,et al.: "Prevalence of GBV-C/HGV infection in pregnant Japanese women" Acta Paediatrica Japonica. 40・3. 385-386 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Miyake Y,Sugiyama K,et al.: "Using polymerase chain reaction to detect the etiological virus of serologically non-A,non-B,non-C fulminant hepatitis" Acta Paediatrica Japonica. 40・1. 102-104 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 杉山幸八郎,三宅能成,他: "輸血関連C型肝炎に重複感染したG型肝炎の小児例" 日本小児科学会雑誌. 100・12. 1923-1925 (1996)

    • Related Report
      1998 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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