• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study for pathogenesis of generalized pustular psoriasis

Research Project

Project/Area Number 09670862
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

OHKAWAWRA Akira  Fac.of Medicine, Hokkaido Univ.Prof., 医学部, 教授 (50000964)

Co-Investigator(Kenkyū-buntansha) MATSUE Hiroyuki  Fac.of Medicine, Hokkaido Univ.Inst., 医学部, 助手 (10250424)
SHIMIZU Tadamichi  Medical Hospital, Hokkaido Univ.Lec., 医学部・附属病院, 講師 (70260396)
KOIZUMI Hiroko  Medical Hospital, Hokkaido Univ.Lec., 医学部・附属病院, 講師 (60113552)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsGeneralized Pustular Psoriasis / HLA / Pustulosis Palmoplantaris / DRB1^*0803 / 汎発性膿疱性乾癬
Research Abstract

Generalized pustular psoriasis is characterized by acute generalized exanthematous pustulosis with general sympstomes in whom do or doesn't has chronic psoriatic plaques. High fever and joint symptome, elevated CRP and erythrocyte sedimentation rate, leukocytosis and hypocalcemiaare noted. Histological features in which neutrophilic invasion into the epidermis with Kogoji's spongiform pustules are characteristic. The pathogenesis of generalized pustular psoriasis remains uncertain, however, infection, pregnancy, menstruation and drugs are considered to be important precipitating factors. Genetic background for psoriasis and generalized pustullar psoriasis has founded. We had studied HLA- A,B, C allels of the patients and found an association to generalized pustular psoriasis. Thus, we investigated the HLA-A,B,C serotypes and DRB1 and DQB1 geno types of 15 unrelated patients with generalized pustular psoriasis and 22 pustulosis palmoplantaris in Hokkaido, Japan. Pustulosis palmoplantaris represents aseptic pustules on palms and soles withoy systemic symptomes. Infections are one of the precipitaing factors of this diseas as well. Pustulosis palmoplantaris showed no significant deviation in HLA studied. The HLA-DRB1*0803 allele was significantly increased in the patients with generalized pustular psoriasis. Our results suggest that HLA-DRB 1 * 0803 contribute to the susceptibility to the Japanese generalized pusutular psoriasis.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] 小林 仁: "尋常性乾癬の治療 ビタミンD_3外用療法" Monthly Book Derma. 2. 53-62 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "尋常性乾癬の治療 レチノイド療法" Monthly Book Derma. 2. 69-73 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T: "Macrophage migrtion inhibitory factor is an essential immunoregulatoly cytokine in atopic dermatitis" Biochem Biophys Res Commun. 240. 173-178 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T: "Identification of macrophage migration inhibitory factor(MIF)in human skin and its immunohistochemical localization." J Invest Dermatol. 20. 171-173 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "1, 25-Dihydroxyvitamine D3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes" Journal of Dermatological Science. 15. 207-213 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "β-Adrenergic stimulation induces activation of protein kinase C and inositol 1, 4, 5-trisphophate increase in epidermis" Experimental Dermatology. 6. 128-132 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase of intracellular Ca^<2+>" Arch Dermatol Res. 290. 264-269 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ozawa A: "HLA class I and Ii alleres ans susceptibility to generalized pustulat psoriasis : significant association with HLA-Cw 1 and HLA-DQB1^*0303." J Dermatol. 25. 873-881 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川嶋利瑞: "汎発性膿疱性乾癬" 皮膚診療. 20. 543-546 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T: "Cis-urocanic acid down-regulates histamine-mediated activation of adenylate cyclase in pig epidermis." Acta Derm Venereol(Stockh). 78. 348-350 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Glucocorticoid decreases stem cell factor produciton in keratinocytes." J Invest Dermatol. 110. 628- (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "H2 histamine receptor-mediated increase in intracellular Ca^<2+> in cultured human keratinocytes." J Dermatol Sci. in print.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobayashi H.: "Vitamin D_3 treatment of psoriasis" Monthly Book Derma. 2. 53-62 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Retinoid therapy of psoriasis" Monthly Book Derma. 2. 69-73 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T.: "Macrophage migration inhibitory factors is an essential immunoregulatory cytokine in atopic dermatitis." Biochem Biophys Res Commun. 240. 173-178 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu.T.: "Identification of macrophage migration inhibitory factor (MIF) in human skin and its immunohistochemical localization." J Invest Dermatol. 20. 171-173 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "1,25-Dihydroxy vitamine D_3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes." J Dermatol Sci. 15. 207-213 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "beta-adreneragic stimulation induces activation of protein kinase C and inositol 1,4,5-trisphosphate increase in epidermis." Exp Dermatol. 6. 128-132 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase of intracellular Ca^<2+>" Arch Dermatol Res. 290. 264-269 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ozawa A.: "HLA class I and II alleres and susceptibility to generalized pustulat psoriasis : significant association with HLA-Cw 1 and HLA-DQB1^*0303." J Dermatol. 25. 873-881 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawashima T.: "Generalized pustular psoriasis" Hifu Shinryo. 20. 543-546 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T.: "Cis-urocanic acid down-regulates histamine-mediated activation of adenylate cyclase in pig epidermis" Acta Derm Venereol (Stockh). 78. 348-350 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Glucocorticoid decreases stem cell factor production in keratinocytes" J Invest Dermatol. 110. 628 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "H2 histamine receptor-mediated increase in intracellular Ca^<2+> in cultured human keratinocytes" J Dermatol Sci. (in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 大河原 章: "汎発性膿疱性乾癬の重症度分類診断基準作成の試み" 厚生省特定疾患皮膚・結合組織疾患調査研究班殺少難治性皮膚疾患分科会平成9年度研究報告書. 44-45 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大河原 章: "汎発性膿疱性乾癬におけるHLA遺伝子型" 厚生省特定疾患皮膚・結合組織疾患調査研究班殺少難治性皮膚疾患分科会平成9年度研究報告書. 49-50 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大河原 章: "スーパー抗原刺激によるヒト末梢血単球サイトカイン生産とレチノイドおよびビタミンD3による抑制効果についての解析" 厚生省特定疾患皮膚・結合組織疾患調査研究班殺少難治性皮膚疾患分科会平成9年度研究報告書. 51-52 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大河原 章: "In vitroにおける好中球浸潤能定量化の試み" 厚生省特定疾患皮膚・結合組織疾患調査研究班殺少難治性皮膚疾患分科会平成9年度研究報告書. 53 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤明: "膿疱性乾癬治療の現状解析とその評価" 厚生省特定疾患皮膚・結合組織疾患調査研究班殺少難治性皮膚疾患分科会平成9年度研究報告書. 46-48 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 稲葉裕: "Pooled controlを用いた膿疱性乾癬の症例対照研究" 厚生省特定疾患皮膚・結合組織疾患調査研究班殺少難治性皮膚疾患分科会平成9年度研究報告書. 39-43 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大河原章: "ヒト単球におけるサイトカイン産生の検討" 厚生少特定疾患稀少難治性皮膚疾患分科会平成8年度研究報告書. 33-38 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大河原章: "膿疱性乾癬における接着分子発現の解析" 厚生少特定疾患稀少難治性皮膚疾患分科会平成8年度研究報告書. 39-43 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大河原章: "汎発性膿疱性乾癬の重症度分類診断基準作成の試み" 厚生少特定疾患稀少難治性皮膚疾患分科会平成9年度研究報告書. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大河原章: "ス-パ抗原刺激によるヒト末梢血単球サイトカイン産生とレチノイドおよびビタミンD_3による抑制効果についての解析" 厚生少特定疾患稀少難治性皮膚疾患分科会平成9年度研究報告書. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大河原章: "汎発性膿疱性乾癬におけるHLA遺伝子型" 厚生少特定疾患稀少難治性皮膚疾患分科会平成9年度研究報告書. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大河原章: "尋常性乾癬の診断と治療" Monthly Book Derma. 2. 1441-1444 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林仁: "尋常性乾癬の治療ビタミンD_3外用療法" Monthly Book Derma. 2. 53-62 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉洋子: "尋常性乾癬の治療レチノイド療法" Monthly Book Derma. 2. 69-73 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimizu T: "Macrophage migrtion inhibitory factor is an essential immunoregulatoly cytokine in atopic dermatitis" Biochem Biophys Res Commun. 240. 173-178 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimizu T: "Identification of macrophage migration inhibitory factor (MIF) in human skin and is immunohistochemical localization." J Invest Dermatol. 20. 171-173 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "1,25-Dihydroxyvitamine D3 and a new analogue,22-oxacalcitriol,modulate proliferation and interleukin-8 secretion of normal human keratinocytes" Journal of Dermatological Science. 15. 207-213 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "β-Adrenergic stimulation induces activation of protein kinase C and inositol 1,4,5-trisphophate increase in epidermis" Experimental Dermatology. 6. 128-132 (1997)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi