• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The expression and the role of autocrine growth factors in differentiation of epidermal keratinocytes

Research Project

Project/Area Number 09670879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionOsaka University

Principal Investigator

HIGASHIYAMA Mari  Osaka University Medical School, Lecturer, 医学部, 講師 (40228713)

Co-Investigator(Kenkyū-buntansha) HIGASHIYAMA Shigeki  Osaka University Medical School, Assistant Professor, 医学部, 助手 (60202272)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsEpidermal Keratinocyte / Cell Differntiation / Autocrine Growth Factor / HB-EGF / TGF-alpha / Involucrin / Keratin 5 and 14 / Keratin 1 and 10 / インポルクリン / ケラチン5、14 / ケラチン1、10
Research Abstract

The growth of keratinocytes is mediated by a variety of growth factors.As far as the EGF family is concerned, TGF-alpha, amphiregulin and HB-EGF have been reported to function as autocrine growth factors for keratinocytes.
The growth of epidermal keratinocytes is associated with cell differentiation.
It is unclear how autocrine growth factors operate in keratinocytes differentiation.In this study immunoreactive HB-EGF was detected in the epidermis of normal human and psoriatic skin.Immnunoreactive HB-EGF in paraffin embedded and formalin fixed tissues were primarily intercellular in basal keratinocytes with a progressive increase in their cytoplasmic localization as the keratinocyies became more differentiated.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Shigeki Inui,Shigeki Higashiyama,Koji hashimoto,Mari Higashiyama et al: "Possible role of coexpression of CD9 with membrane-anchored Heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth" Journal of cellular physiology. 171. 291-298 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shigeki Inui, Shigeki Higashiyama, Koji hashimoto, Mari Higashiyama et al: "Possible role of coexpression of CD9 with membrane-anchored Heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth" Journal of cellular physiology. 171. 291-298 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shigeki Inui,Shigeki Higashiyama,Koji hashimoto,Mari Higashiyama: "Possible role of coexpression of CD9 with membrane-anchored Heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth" Journal of cellular physiology. 171. 291-298 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shigeki Inui, Shigeki Higashiyama, Koji hashimoto, Mari Higashiyama: "Possible role of coexpression of CD9 with membrane-anchored Heparin-binding EGF-like growth factor and amphiregulin in culured human keratinocyte growth" Journal of cellular physiology. 171. 291-298 (1997)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi