| Project/Area Number |
09670894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nara Medical University |
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Principal Investigator |
MIYAGAWA Sachiko Nara Medical University, Department of Dermatology, Associate Professor, 医学部, 助教授 (30094626)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Yoshinao Osaka Medical Center and Research Institute for maternal and child Health, Depar, 代謝部門, 部長 (00250340)
ISHITANI Akiko Nara Medical University, Department of Legal Medicine, Assistant Professor, 医学部, 講師 (40112544)
福本 隆也 奈良県立医科大学, 医学部, 助手 (30264865)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | neonatal lupus erythematosus / congenital heart block / HLA class II genes / Ro / SSA / La / SSB / La / SSB |
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| Research Abstract |
Immunogenetics
(1) HLA class II allele distributions differed among anti-Ro/SSA positive subjects according to the presence or absence of co-existing anti-La/SSB antibodies, but not according to disease expression. Mothers with both anti-Ro/SSA and anti-La-SSB were more likely to have affected infants than mothers with anti-Ro/SSA alone (Autoimmunity, 1997 ; Arthritis Rheum, 1998).
(2) HLA-DR and DQ distributions were different among the groups of anti-Ro/SSA-positive mothers with different neonatal outcomes (J Invest Dermatol, 1997).
(3) HLA-DQAl alleles with glutamine at position of 34 of the first domain, which have reportedly been associated with the autoimmune responses to Ro/SSA antigens, were increased in mothers of infants with cutaneous NLE (J Am Acad Dermatol, 1997, J Invest Dermatol, 1997)
(4) The relationship between fetal and maternal DRB1/DQA1/DQBl genotypes might be important in the immunopathogenesis of congenital heart block (Arthritis Rheum, 1997).
Associations with Sjogren's syndorme
Maternal IgG antibodies bind to a cleaved product of a-fodrin, the recently identified organ-specific autoantigen in primary Sjogren's syndrome (3 Invest Dermatol, 1998).
Pevention of NLE
Prenatal maintenance therapy with prednisolone of betamethasone given to the mother starting early in pregnancy (before 16 weeks' gestation) might reduce the risk of developing antibody-mediated congenital heart block in the offspring (Obstet Gynecol, 1999).
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