| Project/Area Number |
09670912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
HORI Katsuyoshi Institute of Development, Aging and Cancer Department of Vascular Biology, Tohoku University Associate Professor, 加齢医学研究所, 助教授 (00143032)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Sachiko Institute of Development, Aging and Cancer Department of Vascular Biology, Tohok, 加齢医学研究所, 助手 (00125551)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | hyperthermia / microwave / tumor blood flow / angiotensin converting enzyme inhibitor / angiotensin II receptor type I antagonist / combretastatin A-4 |
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| Research Abstract |
The efficacy of hyperthermia therapy is strongly dependent on temperature. However, current hyperthermia equipment including microwave apparatus have revealed an inability to uniformly raise tumor temperatures to above 42ﾟC.It has been considered that one approach to increasing temperatures in the tumors is to lower tissue blood flow thereby decreasing heat loss from the tumor and concurrent lyincreasing temperatures. In this study, we tried to find new materials which induce tumor blood flow reduction and using the material we investigated efficacy of microwave hyperthermia under condition of decrease in tumor blood flow. We obtained the following two results.
1. We discovered that temocapril hydrochloride, an angiotensin converting enzyme inhibitor, losartan, angiotensin II receptor type 1 antagonist, and AC7700, a soluble combretastatin A4 derivative decrease tumor tissue blood flow selectively. In particular, AC7700 induced irreversible stoppage of tumor bloodflow.
2. Therapeutic efficacy of microwave hyperthermia on tumors with the volume of above 5 cm3 was not enhanced by decreasing tumor tissue blood flow due to temocapril hydrochloride.
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