| Project/Area Number |
09670924
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
SAKUMA Hajime Mie University, Hospital, Associate Professor, 医学部・附属病院, 助教授 (60205797)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATO Noriyuki Mie University, Hospital, Lecturer, 医学部・附属病院, 講師 (40214390)
TAKEDA Ken Mie University, Faculty of Medicine, Professor, 医学部, 教授 (70106988)
野村 新之 三重大学, 医学部・附属病院, 助手 (50283536)
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | Coronary blood flow / Magnetic resonance imaging / Hypertrophic cardiomyopathy / Coronary flow reserve / Coronary sinus |
|---|
| Research Abstract |
The purpose of this study was to evaluate coronary blood flow per gram of myocardial mass and vasodilator flow reserve for the entire left ventricle (LV) in hypertrophic cardiomyopathy (HCM) using breath-hold velocity encoded cine (VEC) MR imaging. Twenty-nine patients with HCM and 9 healthy volunteers were studied. Fast VEC MR images were obtained using an oblique imaging plane that was perpendicular to the coronary sinus before and after intravenous administration of dipyridamole (0.56 mg/kg). The products of mean velocity and cross-sectional area of the vessel were integrated to measure blood flow. Breath-hold cine MR images encompassing the entire LV were acquired to quantify LV mass. In the basal state, the coronary blood flow per gram of myocardial mass was 0.74±0.27 ml/min/b in patients with HCM (p=NS). After administration of dipyridamole, coronary blood flow in HCM increased to a level significantly less than that in healthy subjects (1.03±0.40 vs. 2.14±0.51 ml/min/g, p<0.01), resulting in severely depressed flow reserve ratio in HCM compared to normal subjects (1.72±0.49 vs 3.01±0.75, p<0.01). In conclusion, breath-hold VEC MR imaging is a noninvasive technique for evaluating coronary flow per gram of myocardial mass after pharmacological stress and vasodilator flow reserve with HCM.
|
