| Project/Area Number |
09670938
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kagawa Medical University |
|---|
Principal Investigator |
TANABE Masatada Kagawa Medical University Vice President, 副学長 (90033068)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Yoshihiro Kagawa Medical University Department of Radiology, Research Associate, 医学部附属病院, 助手 (50263900)
MORI Yasutane Kagawa Medical University Department of Radiology, Research Associate, 医学部, 助手 (50253282)
TAKASHIMA Hitoshi Kagawa Medical University Department of Radiology, Associate Professor, 医学部, 助教授 (10116402)
OHKAWA Motoomi Kagawa Medical University Department of Radiology, Professor, 医学部, 教授 (70028629)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | ^<123>I-IMP / Pulmonary Scintigraphy / Radiation Pneumonitis / Radiation preumonitis / ^<99m>TC-DTPA / 放射線肺炎 / Dynamic Spect |
|---|
| Research Abstract |
The purpose of this study was to evaluate prediction of radiation pneumonitis by pulmonary scintigraphy using ^<123>I-IMP.Wistar female rats received a single radiation dose of 10, 20, 30 or 40Gy or none, to the right hemithorax using 4MV X-ray. ^<123>I-IMP scintigraphy was performed at 7, 14, and 21 days after irradiation. Imaging was obtained by dynamic acquisition for 60 min after bolus injection. Time-activity curves were obtained by linear plotting on the ROIs set in the irradiated lungs. The observed curves were composed of two phases and were analyzed by using the following formula : C(t)=A_1e^<-k1t>+A_2e^<-k2t>. For analyzing the curves, the sharp decrease during the initial 5min was defined as the fast phase and the slow decrease after 10 min was defined as the slow phase. The halftime for each phase of irradiation was calculated and compared to the normal group. Histological examination of the irradiated lung was also carried out after ^<123>I-IMP in each dose group. Results showed that there was a significant prolongation of the half time during the fast phase in groups studied 14days following irradiation regardless of the dose, as compared to the normal group. There was no significant prolongation of the half time during the slow phase in all irradiated groups regardless of the days following irradiation, as compared to the normal group. Histological findings showed slight cellular infiltration into alveolar septa after all periods of irradiation. These results suggest the possibility that radiation-induced pulmonary changes can be found by the fast phase of the time-activity curve using ^<123>I-IMP scintigraphy even before the histologic evidence of pneumonitis.
|
