| Project/Area Number |
09670953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyorin University |
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Principal Investigator |
NITATORI Toshiaki KYORIN UNIV.SCHOOL OF MED.ASSISTANT PROFESSOR, 医学部, 助教授 (90228247)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Kenichi KYORIN UNIV.SCHOOL OF MED.ASSISTANT, 医学部, 助手
花岡 秀人 杏林大学, 医学部, 助手 (80296540)
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| Project Period (FY) |
1997 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | CORONARY ARTERY / MRI / MRA / CT / CORONARY ANGIOGRAPHY / NON-INVASIVE STUDY / PTCA / coronary vessels / MR / vascnlar studies / vascular studies / angiography / MR imaging |
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| Research Abstract |
Also in Japan, magnetic resonance angiography (MRA) has been expected to provide a useful noninvasive means of assessing coronary artery disease as this disease continues to increase due to westernization of life style. We have investigated the diagnostic value of two-dimensional (2D) and three-dimensional (3D) coronary MRA in clinical patients evaluated for ischemic heart disease. Our results indicate a high correlation between findings on 2D MRA and findings on conventional coronary angiography (CAG) in patients with severe stenosis of proximal arteries. However, in our study involving 153 patients with ischemic heart disease, 2D MRA tended to underestimate lesions in patients with moderate stenotic lesions. Furthermore this method could not be applied successfully in approximately 15% of our patients due to difficulty with breath holding. These findings indicate some of the limitations associated with breath holding in the 2D method. Effective use of 3D MRA with a suitable contrast agent and better spatial ＆ temporal resolution will enable 3D MRA to serve a useful role, even in screening for coronary artery disease. We are now evaluating the usefulness of interactive MRI with 3D MRA to get the image of coronary artery with higher spatial and temporal resolution.
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