| Project/Area Number |
09670955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Juntendo University |
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Principal Investigator |
MAEHARA Tadayuki Faculty of Medicine, Juntendo University, Professor, 医学部, 教授 (60010279)
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| Co-Investigator(Kenkyū-buntansha) |
CHOU Narisumi Faculty of Medicine, Juntendo University, Assistant, 医学部, 助手 (60236833)
IZUKA Yuuou Faculty of Medicine, Juntendo University, Lecturer, 医学部, 講師 (10212713)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | diffusion / Visual pathway / brain function / anisotropy / MRI / 拡散異方性 |
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| Research Abstract |
The purpose of this study is to demonstrate the visual pathway using diffusion-weighted anisotropic MR imaging and evaluate the clinical usefulness of this method for deciding the treatment effect and the prognosis of visual function.
1. As to the imaging plane, the axial image of -4 degree to the anthropological horizontal plane with 10 mm slice thickness is optimum for demonstrating the visual pathway.
2. The most desirable direction of diffusion sensitizing gradient is that along the slice selective direction, in other words, orthogonal to the imaging plane.
3. The ideal b-value is 1200s/mmィイD12ィエD1, but 795 s/mmィイD12ィエD1 is appropriate.
4. The clinical usefulness of this diffusion-weighted MR imaging of the visual pathway was evaluated in several patients with pathologic lesions in the occipital lobe with special reference to the correlation of location of the lesions to the optic pathway. The results showed that the discontinuous optic pathway due to impaired anisotropy by the lesion indicating poor post-treatment prognosis of visual function, on the other hand, the compressed one due to mass effect indicating good prognosis. The diffusion-weighted anisotropic MR imaging is useful for evaluating the optic pathway and can provide useful information about the treatment effect and the prognosis.
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