Analysis of cerebral amine metabolism in mood disorders and anxiety disorders by positron emission tomography.
| Project/Area Number |
09670974
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Gunma University School of Medicine |
|---|
Principal Investigator |
IDA Itsurou Gunma University School of Medicine, Department of Neuropsychiatry, Lecturer, 医学部・神経精神医学講座, 講師 (50251103)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMOYOSHI Katsumi Gunma University School of Medicine, Department of Nuclear Medicine and Diagnost, 医学部・核医学講座, 助手 (60188802)
MIKUNI Masahiko Gunma University School of Medicine, Department of Neuropsychiatry, Professor, 医学部・神経精神医学講座, 教授 (90060508)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
|
|---|
| Keywords | Mood Disorder / Anxiety Disorder / Positron emission tomography / catecholamine / Glucose metabolism / 感情障害 |
|---|
| Research Abstract |
We conducted the measurement of catecholamine metabolism in patients Buffered with mood disorder with PET using anewly synthesized [18F]fluoro- alpha -methyl-L-tyrosine (18F-FAmT), a radioactive tyrosine analogue, as suitable PET tracer forobservation of catecholamine synthesis in living brain. However, no significant difference was observed in 18F-FAmT uptakevalue between patients and controls. We also examined the function of hypothalamic-pituitary-adrenal axis (HPA) indepressed patients using combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test. Approximately 70 %of patients in acute depressive episode were determined as non-suppressors with higher plasma cortisol than controls (morethan 5 mu g/dl after CRH administration). Moreover, 6 non-suppressors showed significant lower glucose metabolism inhippocampal region (p<0.05) as compared with sex and age-matched healthy controls. These results suggest the relationshipbetween the HPA dysfunction and abnormal hippocampal glucose metabolism in mood disorders.
|
Report
(3 results)
Research Products
(3 results)
