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What kind of neural circuit in the brain of prenatally stressed offspring may be responsible to the vulnerabill to chronic stress in adulthood

Research Project

Project/Area Number 09670975
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionGunma University School of Medicine

Principal Investigator

MIKUNI Masahiko  Department of Neuropsychiatry, Professor and Chairman Univ., Associate Professor, 医学部, 教授 (00125353)

Co-Investigator(Kenkyū-buntansha) IDA Ituro  Department of Neuropsychiatry, Senior Lectuerer, 医学部, 講師 (50251103)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsprenaral stress / animal model / vulnerability / neuronal plasiticity / septum / hypothalomo-pituitary-adrenal axis
Research Abstract

It has been suggested that early adverse life events including childhood abuse, neglect, and parental loss may predispose individuals for the development of affective disorders in response to extreme stress exposure in adulthood. Recently, we have demonstrated that the prenatal saline injection stress produced an enhanced adrenocortical response to conditioned fear stress and a prolonged immobility duration in forced swimming stress, indicating that the prenatally stressed offspring seemed to be susceptive to an acute stress in adulthood endocrinologically and behaviorally. It is still unclear whether prenatally stressed rats can habituate to chronic stress in adulthood. We have investigated the stress response of c-fos mRNA expression in brain and of corticosterone secretion in prenatally stressed adult male rats during 14 days repeated restraint stress. To an acute restraint stress, prenatally stressed rats showed significantly increased response of c-fos mRNA expression, to the same extent, compared to control rats, in brain regions including para-ventricular nucleus, amygdala, locus ceruleus, raphe nucleus, cingulate cortex, piriform cortex, and seputum. Repeated restraint stress for 14 days induced significant reduction of c-fos response, compared to the expession of c-fos mRNA during acute restraint stress, in all investigated brain regions except septum of prenatally stressed rats. In septum, prenatally stressed rats showed significant increase in c-fos expression in response to repeated restraint stress, compared to control rats. In addition, control rats showed reduction of plasma corticosterone level at 120min after the beginning of restraint stress from the 7th day of stress, whereas prenatally stressed rats did not show such habituation. These findings indicate that the neural circuit including septum may be responsible to the vulnerabillty of prenatally stressed rats to chronic stress in adulthood.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Hiroshi Inoue, Masahiko Mikuni, et al: "A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram Syndrome )." Nature Genetics. 20. 143-148 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomio Inoue, Masahiko Mikuni ,et al: "F-18 α-methyl tyrosine PET studies in patients with brain tumors." J.Nuclear Medicine. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katsumasa Muneoka, Masohiko Mikuni, et al: "Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring." Am.J.Physiology. 273. R1669-E〓75 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mari Tokunaga, Masahiko Mikuni, et al: "Alterations of benzodiazepine receptor binding potential in anxiety and somatoform disorders." Radiation Medicine. 15. 163-169 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三國雅彦: "グルココルチコイドと精神症状-その分子機序とうつ病態解明に向けて" 神経研究の進歩. 42. 656-665 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三國雅彦: "感情障害における神経発達学的側面" 脳の科学. 20. 767-773 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三國雅彦、樋口輝彦編: "脳シグナルカスケードと精神疾患" 学会出版センター, 238 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 三國雅彦、高橋清久編: "生体リズムと精神疾患" 学会出版センター, 236 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomio Inoue, Takashi Shibasaki, Noboru Oriuchi, Keiko Aoyagi, Katsumi Tomiyoshi, Shigeko Amano, Masahiko Mikuni, Itsuro Ida, Jun Aoki, and Keigo Endo: "F-18 alpha-methyl tyrosine PET studies in patients with brain tumors." J.Nuclear Medicine. 40. 418-421 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiroshi Inoue, Yukio Tanizawa, Jon Wasson, Philip Behn, Kamini Kalidas, Ernesto Bernal-Mizrachi, Mike Mueckler, Helen Marshall, Helen Donis-Keller, Patricia Crock, Douglas Rogers, Masahiko Mikuni, Hisashi Kumashiro, Koichiro Higashi, Gen Sobue, Yoshitomo Oka, M.Alan Permutt.: "A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram Syndrome)." Nature Genetics. 20. 143-148 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katsumasa Muneoka, Masahiko Mikuni, Tetsuo Ogawa, Katsuki Kitera, Kenji Kamei, Morikuni Takigawa, Kiyohisa Takahashi: "Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring." Am.J.Physiology. 273. R1669-R1675 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mari Tokunaga, Ituro Ida, Teruhiko Higuchi, Masahiko Mikuni: "Alterations of benzodiazepine receptor binding potential in anxiety and somatoform disorders." Radiation Medicine. 15. 163-169 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiroshi Inoue,Masahiko Mikuni,et al: "A gene encoding a transmembrane protein is mutated in patients with deabetes mellitus and optic atrophy (Wolfram Syndrome)" Nature Genetics. 20. 143-148 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tomio Inoue,Masahiko Mikuni,et al: "F-18 α-methyl tyrosine PET studies in patients with brain tumors." J. Nuclear Medicine. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Katsumasa Muneoka,Masahiko Mikuni,et al: "Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring." Am. J. Physiology. 273. R1669-R1675 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mari Tokunaga,Masahiko Mikuni,et al: "Alterations of benzodiazepine receptor binding potential in anxiety and somatoform disorders." Radiation Medicine. 15. 163-169 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三國雅彦: "グルココルチコイドと精神症状-その分子機序とうつ病態解明に向けて" 神経研究の進歩. 42. 656-665 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三國雅彦: "感情障害における神経発達学的側面" 脳の科学. 20. 767-773 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三國雅彦、樋口輝彦編: "脳シグナルカスケードと精神疾患" 学会出版センター, 238 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三國雅彦、高橋清久編: "生体リズムと精神疾患" 学会出版センター, 236 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tokunaga M, Ida I, Higuchi T, Mikuni M: "Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring." Am.J.Physiology. 273. R1669-R1675 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Muneoke K, Mikuni M, Ogawa T, Kitera K, Kamei K, et al: "Alterations of benzodiazepine rcceptor binding potential in anxiety and somatoform disorders." Radiation Medicine. 15. 163-169 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中村彰治, 渡辺義文 三国雅彦: "うつ病の病態をめぐって" 生体の科学. 48. 58-61 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三国 雅彦: "発達期のストレスと神経系の可塑性並びに感情障害脆弱性" 医事新報. 3815. 105 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三国 雅彦: "胎生期や新生児期のストレスはラットのその後のストレス反応性を規定する要因のひとつである。" ストレス科学. 11. 272-278 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三国 雅彦: "神経発達学的視点からみた精神疾患と脳科学" 脳と精神の医学. 8. 365-374 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三国 雅彦: "「感情障害の受容体-細胞内情報伝達系機能障害」脳シグナルカスゲ-ドと神経疾患" 三国雅彦、樋口輝彦編、学会出版センター、東京、, 161-180 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三国 雅彦: "「胎生期ストレスによる神経の発達に伴う可塑的変化と感情障害病態モデル」感情機能と神経・免疫・内分泌-脳の世紀に向けて" 山脇成人編、親興医学出版社、東京、, 55-67 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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