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receptor studies on schizophrenia

Research Project

Project/Area Number 09670980
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Medical and Dental University School of Medicine

Principal Investigator

HANAMURA Seiichi  Tokyo Medical and Dental University School of Medicine, Depatrment of Neuropsychiatry, Research Associate, 医学部, 助手 (40107256)

Co-Investigator(Kenkyū-buntansha) TORU Michio  Tokyo Medical and Dental University School of Medicine, Depatrment of Neuropsych, 医学部, 名誉教授 (20013972)
SUHARA Tesuya  National Institute of Radiological Sciences, Division of Advanced Technology for, 高度診断機能研究ステーション, 主任研究官 (90216490)
OKUBO Yoshiro  Tokyo Medical and Dental University School of Medicine, Depatrment of Neuropsych, 医学部, 助教授 (20213663)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsPET / Schizophrenia / Dopamine / Serotonin / セロトニンS2受容体 / ドーパミンD1受容体
Research Abstract

D2 dopamine receptors are of central interest for gaining a better understanding of the pathophysiology of schizophrenia.. The highest D2 dopamine receptor densities have been found in the caudate nucleus and putamen. However, recent studies with PET have failed to show any change in D2 receptor densities in the striatum of schizophrenics. Several studies in patients with schizophrenia have suggested a disturbed function of non-dopamine or extrastriatal D2 dopamine receptor systems in schizophrenia. We used PET to examine the distribution of 5-HT2 receptors in brains of drug-naive or drug-free schizophrenic patients. No differences were observed in the cortex relative to control subjects. The Computerized Brain Atlas (CBA) transforms PET images of individual subjects into a standard brain shape and size and makes it possible to apply the anatomy database consisting of three-dimensional borders of detailed brain structures. we aimed to explore the regional distribution of extrastriatal D2 dopamine receptors in healthy subjects using [llC]FLB 457, a substituted benzamide with very high affinity for D2 dopamine receptors, and PET with the anatomic standardization technique. PET with [11C]FLB 457 has made it possible to build a normal database of the extrastriatal D2 dopamine receptors in the living human brain, and the heterogeneous distribution of D2 receptors provides an attractive opportunity for performing new and exciting research on schizophrenia and antipsychotic drug action.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Okubo Y,Suhara T,Sudo Y,Toru M.: "Possible role of dopamine D1 receptors in schizophrenia.An example of comparison of PET images of dopamine D1 receptors between a schizophrenic" Molecular Psychiatry. 2. 291-294 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Arinami T,Otsuka Y,Hamaguchi H,Itokawa M,Aoki J,Shibuy H,Okubo Y et al.: "Evidence supporting an association between the DRB1 gene and schizophrenia in Japanese." Schizophrenia Research. 32. 81-86 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito H,Okubo Y,Halldin C,Farde L: "Dopamine receptors in man using [11C] raclopride : PET with anatomic standardization technique" Neuroimages. 7. in press (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nyberg S,Nilsson U,Okubo Y,et al.: "Implications of brain imaging for the management of schizophrenia" International Clinical Psychopharmacology. 13(Suppl 3). S15-S20 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sudo Y,Suhara T,Honda Y,Nakajima T,Okubo Y,et al.: "Muscarinic cholinergic receptors in human an narcolepsy - A PET study" Neurology. 51. 1297-1302 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suhara T,Sudo Y,Yoshida K,Okubo Y,et al.: "Lung as reservoir for antidepressants in pharmacokinetic drug interactions" Lancet. 351. 332-335 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koyama K,Hirasawa H,Okubo, Y,Karasawa A.: "Quantitative EEG correlates of normal aging in the elderly" Clin Electroencephalograhy. 28. 160-165 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okubo Y,Suhara T,Sudo Y,Toru M.: "Possible role of dopamine D1 receptors in schizophrenia. An example of comparison of PET images of dopamine D1 receptors between a schizophrenic patient and acontrol subject" Molecular Psychiatry. 2. 291-294 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yana K,Mizuta H,Kawachi K,Yoshida H,Iida K,Okubo Y,Tohru M,Okuyama F.: "Decision support for psychiatric diagnosis based on a simple questionnaire" Methods of Information in Medicine. 36. 349-351 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Adachi N,Onuma T,Hara T,Oana Y,Matsuura M,Okubo Y,Takei N.: "Is postictal psychosis a separate clinical entity ?" MAJKOWSKI J,OWCZAREK K,ZWOLINSKI P,ed.3rd EUROPEAN CONGRESS OF EPILEPTOLOGY.Warsaw, Poland. 349-353 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Arinami T,Otsuka Y,Hamaguchi H,Itokawa M,Aoki J,Shibuya H,Okubo Y,Iwawaki A,Ota K,Enguchi H,Tagaya H,Yano S,Shimizu H,Toru M.: "Evidence supporting an association between the DRB1 gene and schizophrenia in Japanese." Schizophrenia Research. 32. 81-86 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishiguro H,Ohtsuki T,Toru M,Itokawa M,Aoki J,Shibuya H,Kurumaji A.Okubo Y,Iwawaki A,Ota K,Shimizu H,Hamaguchi H,Arinami T.: "Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia. Neuroscience Letters." 257. 45-48 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito H,Okubo Y,Halldin C,Farde L.: "Dopamine receptors in man using [11C] raclopride : PET with anatomic standardization technique" Neuroimage. 7 : (in press.). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nyberg S,Nilsson U,Okubo Y,Halldin C,Farde L.: "Implications of brain imaging for the management of schizophrenia. International Clinical Psychopharmacology" 13(suppl.3). S15-S20 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sudo Y,Suhara T,Honda Y,Nakajima T,Okubo Y,Suzuki K,Nakashima Y,Yoshikawa K,Okauchi T,Sasaki Y,Matsushita M.: "Muscarinic cholinergic receptors in human narcolepsy-A PET study." Neurology. 51. 1297-1302 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suhara T,Sudo Y,Yoshida K,Okubo Y,Fukuda H,Obata T,Yoshikawa K,Suzuki K,Sasaki Y.: "Lung as reservoir for antidepressants in pharmacokinetic drug interactions" Lancet. 351. 332-335 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirai N,Uchida S,Maehara T,Okubo Y,Shimizu H.: "Enhanced gamma (30-50Hz) frequency in the human parahippocampal gyrus." Neuroscience. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Girard F,Suhara T,Sassa T,Okubo Y,Obata T,Ikehira H,Sudo Y,Koga M,Yoshioka S,Yoshida K.: Direct two/dimensional spectroscopic imaging of lithium. Recent Advances in Biomedical Imaging.225-232 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hara K,Okubo Y,Terasaki O,Toru M.: Alcohol-induced alteration in EEG as a biological marker for alcoholism : dipole estimation of alpha rhythm. Koga Y,Nagata K,Hirata K,ed.Brain Topography Today. Amsterdam : Elsevier, 450-454 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okubo Y,Suhara T,Sudo Y,Toru M: "Possible role of dopamine D1 receptors in Schizophrenia An example of comparison of PET images of dopamine D1 receptors between a schizophrenic" Molecular Psychiatry. 2. 291-294 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Arinami T,Otsuka Y,Hamaguchi H,Itokawa M,Aoki J,Shibuya H,Okubo Y,et al.: "Evidence supporting an association between the DRB1 gene and schizophrenia in japanese" Schizophrenia Research. 32. 81-86 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito H,Okubo Y Halldin C,F rdeL: "Dopamine receptors in man using [IIC]raclopride:PET with automic standardization technique" Neuroimage. 7(in press). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nyberg S,Nilsson U,Okubo Y et al: "Implications of brain imaging for the management of Schizopherenia" International Clinical Psychopharmacology. 13(Suppl 3). S15-S20 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sudo Y,Suhara T,Honda Y,Nakajima T,Okubo Y et al.: "Muscarinic cholinergic receptors in human narcolepsy -A PET study" Neurology. 51. 1297-1302 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suhara T,Sudo Y,Yoshida K,Okubo Y et al.: "Lung as reservoir for antidepressants pharmacokinetic drug interactions" Lancet. 351. 332-335 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okubo,Y, Suhara,T et al: "Possible role of dopamice D1 receptors in schlzophneula" Moleailor Psychintry. 2. 291-294 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suhara,T, Suda,Y, Yoshida, Okubo,Y, et al: "Lung as a reservoir for antidepressconts in pharmacoltinetic drug interactions" Lancet. 351. 332-335 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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