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Relationships between polymorphisms of genes encoding neurotrophic factors and neurodevelopment in schizophrenia

Research Project

Project/Area Number 09671008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTEIKYO UNIVERSITY

Principal Investigator

KUNUGI Hiroshi  Teikyo University School of Medicine, Lecturer, 医学部, 講師 (40234471)

Co-Investigator(Kenkyū-buntansha) LEE Kyu-Bak  Teikyo University School of Medicine, Assistant, 医学部, 助手 (40307202)
NANKO Shinichiro  Teikyo University School of Medicine, Professor, 医学部, 教授 (60101127)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsSchizophrenia / Neurotrophic factor / Molecular genetics / Hippocampus / Neurodevelopment / Neurotrophin-3 / Brain derived neurotrophic factor / ニューロトロフィン-3 / 関連研究
Research Abstract

Polymorphisms of gens encoding neurotrophic factors are possibly involved in the pathogenesis of schizophrenia. We searched for polymorphisms in the neurotrophin-3 (NT-3), brain derived neurotrophic factor (BDNF), and glial cell-line derived neurotrophic factor (GDNF) genes and explored their effects on susceptibility and neurodevelopmental abnormalities in schizophrenia.
The Gly(-63)Glu polymorphism of the NT-3 gene was not significantly associated with susceptibility to schizophrenia when severity of the disease was not taken into account. A nucleotide substitution was found in the vicinity of the AP-1 binding site of the NT-3 gene ; however, it was not associated with susceptibility to schizophrenia. A dinucleotide repeat polymorphism of the NT-3 gene, which was previously reported to be associated with the risk of schizophrenia, was found to be associated with reduced volume of hippocampi in schizophrenic subjects, suggesting that this polymorphism may exert an effect on the development of schizophrenia through neurodevelopmental abnormalities of the CNS including hippocampus. We found two nucleotide substitutions in the promoter and 5 untranslated regions of the BDNF gene. These polymorphisms were suggested to be associated with the risk of developing schizophrenia. We could not find any polymorphism for the GDNF gene.
Based on information from the Maternal and Child Health Handbook, we confirmed the prenatal underdevelopment in schizophrenia, including development of the eNS.However, there was no significant association of Gly(-63)Glu or the dinucleotide repeat polymorphism of the NT-3 gene with head circumference at birth of schizophrenics.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Kunugi H 他: "Pinncleofide repeut polynorphism in the nemotrephin-3 gene and hippocanpol volume in psychoses" Schizophrenia Research. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kunugi H,Kato T,Fujii K,Hattori M,Kato N,Nanko S: "Dinucleotide repeat polymorphism in the neurotrophin-3 gene and hippocampal volume in psychoses." Schizophrenia Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kunug:H 他: "Dinucleotide repest polymorphism in the newrotrophin-3 gene and hippocampal volune in psydroses." Schizophrenia Research. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sasaki T,Doix Y,Kuwata S,et al.: "Brain-derived neurotrophic factor gene and schizophrenia in Japanese subjects." American Journal of Medical Genetics. 74巻. 443-444 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakai T, Sasaki T,Tatsumi M et al.: "Schizophrenia and the ciliary neurotrophic factor(CNTF)gene:noevidence for association." Psychiatry Research. 71巻. 7-10 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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