| Project/Area Number |
09671184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
ANDO Minoru 4th Dept of Tokyo Woman's Medical Univ. (Research Assistant), 医学部, 助手 (20246474)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Uremia / Scavenger receptor / M-CSF / hyperparathyroidism / Osteoblast / 腎不全 / スカベンジャー・リセプター |
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| Research Abstract |
Research I. Clinical significance and characterization of elevated serum M-CSF in dialysis patients with emphasis on atherosclerosis
Summary 1 :
We speculated that one of the causes of elevated serum M-CSF is an osteoblast that is strongly stimulate by hyper parathyroidism which is rather common in dialysis patients.
Research II. Atherosclerosis in uremic mice model : In vivo relevance of SR and M-CSF to uremia-associated atherosclerosis
Summary 2 :
Our data suggested that uremic condition itself accelerated atherosclerosis and under a hyperlipidemic diet. The crosstalk among SR expression, M-CSF, and atherosclerosis is not clear as yet in this study. In addition, in vivo secondary hyperparathyroidism observed in uremic patients though, exogenous PTH may elevate M-CSF from bone, leading to the elevation of serum levels of M-CSF.
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