| Project/Area Number |
09671197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Showa University |
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Principal Investigator |
TAKEUCHI Toshio School of Medicine, Showa Univ. Assistant Professor, 医学部, 助教授 (50206950)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Makoto Inouer Chiba Children Hospital Assistant, 新生児未熟児科, 医員
IIKURA Yuji School of Medicine, Showa Univ. Professor, 医学部, 教授 (30056882)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Chronic lung disease / Energy Expenditure / Oxygey consumption / Trypsin / Lipase / 二酸化炭素排泄量 / トリプシン活性 / リパーゼ活性 |
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| Research Abstract |
Undernutrition and growth failure in infants with chronic lung disease (CLD) remains one of the major clinical problems for pediatricians, but the cause is unknown. Recent reports showed that undernutrition is a major contributing factor in the pathogenesis of CLD. We measured the energy metabolism and the activities of lipase and trypsin in aspirated duodenal juice of very low birth weight infants (VLBWI) with and without CLD. To examine the difference in energy metabolism of 13 VLBWI (6 cases with CLD, 7cases without CLD), a metabolic gas monitor (MGM/jr.) was used to obtain oxygen consumption and carbon dioxide production. Oxygen consumption (9.9±1.3 versus 8.5±1.1 ml/kg/min : p<0.05), and energy expenditure (71.6±10.3 versus 61.1±7.9 kcal/kg/day : p<0.05) were higher in infants with CLD. Total energy intake ( 80.2±11.9 versus 98.2±7.9 kcal/kg/day : p<0.01) was lower in infants with CLD. The activities of lipase and trypsin were measured in preprandially aspirated duodenal juice of 20 VLBWI during 8 weeks of postnatal period. The activities of both enzymes significantly increased with postnatal age. These 20 infants were allocated into two groups according to oxygen supplemented period and ventilatory supported period. The pancreatic enzyme activity of the infants who needed longer OィイD22ィエD2 supplementation and ventilatory support were lower than the others. From these results, we concluded that careful and individual nutritional management was needed in the VLBW infants with CLD who require long term ventilatory supports.
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