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correlation between venous insufficiency and valve function in deep vein thrombosis

Research Project

Project/Area Number 09671213
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionUNIVERSITY OF TOKYO

Principal Investigator

KAWAMURA Yutaka (1998)  University of Tokyo, Surgery, Assistant, 医学部・附属病院, 助手 (80301109)

新本 春夫 (1997)  東京大学, 医学部附属病院, 助手

Co-Investigator(Kenkyū-buntansha) HOSOI Yutaka  University of Tokyo, Surgery, Assistant, 医学部・附属病院, 助手
KOMIYAMA Takashi  University of Tokyo, Surgery, Assistant, 医学部・附属病院, 助手 (10292947)
YASUHARA Hiroshi  University of Tokyo, Surgery, Lecturer, 医学部・附属病院, 講師 (50251252)
SHIGEMATSU Hiroshi  University of Tokyo, Surgery, Assistant Professor, 医学部・附属病院, 助教授 (40134556)
畠山 卓弥  東京大学, 医学部附属病院, 助手 (60291324)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsnear-infrared spectrosopy / venous insufficiency / deep vein thrombosis / deoxygenated hemoglobin / venous valve function
Research Abstract

Patients with chronic venous insufficiency (CVI) were evaluated from the aspect of ambulatory venous function using near-infrared spectroscopy (NIRS). Patients with primary varicose veins and volunteers with normal limbs were studied. The affected limbs of the patients were divided into three groups according to their clinical signs and symptoms. All of the patients underwent a treadmill walking test, during which NIRS was applied. Oxygenated hemoglobin (OxyHb) and deoxygenated hemoglobin (DeoHb) were continuously measured by NIRS during exercise. The ambulatory venous retention index (AVRI) obtained from serial changes in DeoHb was assessed comparatively in the four groups (normal and mild to severe CVI). Two distinct patterns of DeoHb change were observed. During exercise, the DeoHb level decreased in the normal group due to calf muscle contraction, whereas, in the varicose group, . the DeoHb level rose because of an apparent venous reflux into the calf muscles. AVRI studies demonstr … More ated a significant difference (p<O.OOOl) among groups. NIRS is useful for accurately assessing ambulatory venous dysfunction in patients with primary varicose veins.
To determine the influence of the site affected by thrombi on the subsequent venous physiology, we examined patients with post-thrombotic syndrome (PTS) with respect to ambulatory venous function using NIRS.Patients, in whom more than one year had passed since an acute episode of deep vein thrombosis (DVT), were studied. The mean duration of PTS was 8.2 years. All of the patients underwent a treadmill walking lest with simultaneous NIRS.DeoHb was continuously measured during exercise. The AVRI obtained from the serial DeoHb changes was calculated in each patient. The location of thrombi at the onset of DVT was identified by venography. The calculated AVRI was apparently related to the clinical symptoms of PTS.The limbs initially involved with popliteal vein thrombosis showed significantly higher AVRI values than those without popliteal vein thrombosis. The clinical severity of PTS is correlated well with the degree of venous retention during exercise. Initial involvement of the popliteal vein is an important factor determining subsequent venous hemodynamics in patients with PTS.
To investigate the diagnostic value of NIRS for the detection of DVT, particularly isolated calf DVT, in comparison with air plethysmography (APG), patients with clinically suspected DVT were studied. All patients were examined by venography and APG.Patients also underwent a treadmill-walking test with simultaneous NIRS.The AVRI obtained from serial DeoHb changes was calculated in each patient. Tue overall sensitivity of NIRS and APG was 97% and 80%0, respectively. NIRS was more sensitive than APG for detecting isolated calf DVT (89% and 22%, respectively), while both tests identified proximal DVT in all limbs. NIRS is a highly sensitive method for the diagnosis of hemodynamically significant DVT. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] 重松 宏: "閉塞性動脈硬化症による間歇性跛行に対するアルガトロバンの薬効評価-近赤外分光法を用いた検討-" Therapeutic Research. 18(11). 3665-3672 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 重松 宏: "血栓塞栓症治療の新しい展開" 日本医師会雑誌. 118(12). 1663-1677 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 重松 宏: "末梢血管障害の病態と最近の話題" Pharma Medica. 15(12). 85-89 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosoi Y: "A new method for assessment of venous insufficiency in primary varicose veins using near-infrared spectroscopy" Journal of Vascular Surgery. 26(1). 53-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細井 温: "Postthrombotic syndromeの近赤外線分光法による運動時の血行動態学的検討-下肢静脈瘤症例との比較" 静脈学. 9(3). 227-231 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小見山 高士: "末梢動脈塞栓症" 血栓と循環. 5(2). 169-173 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 重松 宏: "抗トロンビン薬-臨床応用への新しい展開" Therapeutic Research. 19(5). 1391-1397 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細井 温: "下肢静脈瘤に対する治療法の選択" 手術. 52(6). 777-781 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細井 温: "近赤外分光法による間歇性跛行に対する評価" Progress in Medicine. 19(2). 280-283 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosoi Y: "Influence of popliteal vein thrombosis on subsequent ambulatory venous function measured by near-infrared spectroscopy" The American Journal of Surgery. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosoi Y: "Comparison of near-infrared spectroscopy with air plethysmography in detection of deep vein thrombosis" International Angiology. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shigematsu H: "Diabeties and peripheral arterial occlusion" Asian Medical Journal. 41(5). 253-260 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細井 温: "血管疾患の無侵襲診断法" 医歯薬出版, 6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Sigematsu: "An evaluation of Arugatroban effects for claudicants with ASO-Study using near-infrared spectroscopy-" Therapeutic Research. 18(11). 3665-3672 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shigematsu: "New aspects for treatment of acute arterial embolism" Nihon Isikai Zasshi. 118(12). 1663-1667 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shigematsu: "Peripheral arteril disease and current topics." Pharma Medica. 15(12). 85-89 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shigematsu: "Anti-thrombin. New aspects for clinical application" Therapeutic Research. 19(5). 1391-1397 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: "A new method for assessment of venous insufficiency in primary varicose veins using near-infrared spectroscopy." Journal of Vascular Surgery. 26(1). 53-60 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: "Strategy for the treatment of varicose veins" Shujutu. 52(6). 777-781 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Komiyama: "Peripheral arterial occlusion" Thrombosis and Circulation. 5(2). 169-173 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shigematsu: "Diabetes militus and peripheral arterial occlusion." Asian Medical Journal. 41(5). 253-260 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: "Assessment of venous hemodynamics in patients with postthrombotic syndrome using near-infrared spectroscopy" Japanese Journal of Phlebology. 9(3). 227-231 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: "Assessment of intermittent claudication by the use of near-infrared spectroscopy" Progress in Medicine. 19(2). 280-283 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: "Influence of popliteal vein thrombosis on subsequent ambulatory venous function measured by near-infrared spectroscopy" The American Journal of Surgery. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: "Comparison of near-infrared spectroscopy with air plethysmography in detection of deep vein thrombosis" International Angiology. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hosoi: Noninvasive diagnosis for vascular diseases. Ishiyaku-shuppan, Tokyo, 247-248 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 重松 宏: "抗トロンビン薬-臨床応用への新しい展開" Therapeutic Research. 19(5). 1391-1397 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細井 温: "下肢静脈瘤に対する治療法の選択" 手術. 52(6). 777-781 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細井 温: "近赤外分光法による間歇性跛行の対する評価" Progress in Medicine. 19(2). 280-283 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hosoi Y: "Influence of popliteal vein thrombosis on subsequent ambulatory venous function measured by near-infrared spectroscopy" The American Journal of Surgery. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Hosoi Y: "Comparison of near-infrared spectroscopy with air plethysmography in delection of deep vein thrombosis" International Angiology. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Shigematsu H: "Diabeties and peripheral arterial occlusion" Asian Medical Journal. 41(5). 253-260 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細井 温: "血管疾患の無侵襲診断法" 医歯薬出版, 6 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 重松 宏: "閉塞性動脈硬化症による間歇性跛行に対するアルガトロバンの薬効評価-近赤外分光法を用いた検討-" Therapeutic Research. 18 (11). 3665-3672 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 重松 宏: "血栓塞栓症治療の新しい展開" 日本医師会雑誌. 118 (12). 1663-1677 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 重松 宏: "末梢血管障害の病態と最近の話題" Pharma Medica. 15 (12). 85-89 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hosoi Y: "A new method for assessment of venous insufficiency in primary varicose veins using near-infrared spectroscopy" Journal of Vascular Surgery. 26 (1). 53-60 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細井 温: "Postthrombotic syndromeの近赤外線分光法による運動時の血行動態学的検討-下肢静脈瘤症例との比較" 静脈学(掲載予定). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小見山 高士: "末梢動脈塞栓症" 血栓と循環. 5 (2). 169-173 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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