| Project/Area Number |
09671233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kagawa Medical University |
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Principal Investigator |
USUKI Hisashi Kagawa Medical University, Medicine, Assiatant Professor, 医学部附属病院, 講師 (90232834)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Hiroshi Yamagata University, Enginering, Associate Professor, 工学部, 助教授 (60250958)
ONO Mitsuhiro Yamagata University, Enginering, Professor, 工学部, 教授 (60007010)
GODA Fuminori Kagawa Medical University, Medicine, Research Associate, 医学部附属病院, 助手 (90294769)
MAETA Hajime Kagawa Medical University, Medicine, Professor, 医学部, 教授 (00075508)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | in vivo ESR oximetry / surface coil type resonator / oxygen tension in tissue / clinical use / electron spin resonance |
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| Research Abstract |
In vivo ESR oximetry is being used to obtain measurements of partial oxygen tension in tissue of biological systems with an ease and accuracy that has not been possible previous other methods. It appears quite possible that the technique will become a widely used clinical tools. The developments of ESR oximetry needs following three parts of investigations to obtain ESR spectra in moving animals and human subjects.
1) Improvements of ESR spectrometer. We investigated a flexible surface-coil type resonator for this purpuse.
2) The discovery and developments of oxygen sensitive paramagnetic materials. We have tested more than 120 carbon materals and two carbon materals were chosen for this purpose. To improve the oxygen sensitivty, Polymer coating techniques are under the investigations.
3) Mesurements of oxygen tension in biological systems. We demonstrated the changes of oxygen tension in tissue directly, i.e. affect of anesthesia on tissue oxygen tension in mice and rats, re-oxygenation in tumor tissue after radiation and chemothrapy in mice, the change of oxygen tension in kidny at the time of endotoxin shock using rats.
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