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Application of heat-treated mandiblar bone

Research Project

Project/Area Number 09671267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKurume University

Principal Investigator

KIYOKAWA Kensuke  Kurume University School of Medicine, Associate Professor, 医学部, 助教授 (10195399)

Co-Investigator(Kenkyū-buntansha) TANAKA Shinsuke  Kurume University School of Medicine, Lecturer, 医学部, 助手 (70289495)
YANAGA Hiroko  Kurume University School of Medicine, Assistant Professor, 医学部, 講師 (70217107)
TAI Yoshiaki  Kurume University School of Medicine, Professor, 医学部, 教授 (20081789)
早川 宏司  久留米大学, 医学部, 助手 (00228553)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Keywordsmandiblar reconstruction / egenerative medicine / heat-treated bone / iliac cancellous bone / BMP / 下顎再建 / 骨移植 / 筋皮弁 / インプラント
Research Abstract

Reconstruction of the mandible and oral cavity is quite important after surgical treatment for malignant tumor. For this purpose, bone graft with vascular pedicle, skin flap, and/or muscle flap are utilized, but they are associated with significantly large invasion and long surgery time. In order to solve these problems, we examined applicability of regenerative medicine, and applied the findings to 2 patients. In the experiment using white rabbits, unilateral femur was surgically resected, cortex bone after removing bone marrow was boiled in 100℃ physiological saline for 30 min or longer, then bone marrow was returned into the cortex bone, it was divided into 2 pieces, and grafted subcutaneously or intramuscularly on the back. One month later, the rabbits were sacrificed, the grafted bone was resected, and examined radiographically, with CT, and histologically. As a result, significantly better bone regeneration was observed in the bone grafted in the muscle. This showed the mandible can be regenerated at the resected area by using heat-treated cortical bone(mandible), iliac cancellous bone(bone marrow)and a muscle flap. This knowledge was clinically applied to 2 patients who had recurrent oral cancer. The resected mandible was separated from the other tissues, bone marrow was removed, and the cortical bone was boiled after making many small holes. This heat-treated bone was fixed on the area of oral defect by using a titanium plate, iliac cancellous bone was grafted into the lumen, and the entire surrounding area was covered with the muscle flap made from the greater pectoral muscle. The skin island of the flap was used for the reconstruction of oral cavity. The 2 patients have good clinical outcomes, regained almost normal shape of the mandible, and there were no postoperative complications. Regeneration of the mandible was confirmed with radiographs and bone scintigraphy.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 清川兼輔: "悪性腫瘍切除後の下顎と口腔再建"形成外科. 40巻増刊号. S105-S113 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kensuke Kiyokawa: "Oromandibular reconstruction after surgical resection of malignant tumor."The Japanese Journal of Plastic and Reconstructive Surgery. 40. S105-S113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 清川兼輔: "悪性腫瘍切除後の下顎と口腔再建"形成外科. 40巻増刊号. S105-S113

    • Related Report
      2000 Annual Research Report
  • [Publications] 清川兼輔 他: "悪性腫瘍切除後の下顎の口腔再建"形成外科. 40巻増刊号. S105-S113 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清川兼輔 他: "悪性腫瘍切除後の下顎の口腔再建" 形成外科. 40巻増刊号. S105-S113 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 清川兼輔 他: "悪性腫瘍切除後の下顎の口腔再建" 形成外科. 40巻増刊号. S105-S113 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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