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Modulation of excessive responses by surgical stress using steroids

Research Project

Project/Area Number 09671274
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTOHOKU University

Principal Investigator

SHINEHA Ryuzaburo  Tohoku Univ.Sch.Med.Surgery II,Lecturer, 医学部, 講師 (20192106)

Co-Investigator(Kenkyū-buntansha) TAMURA Shinri  Tohoku Univ.Sch.Med.Surgery II,Professor, 医学部, 教授 (20124604)
ORII Takashi  Tohoku Univ.Sch.Med.Surgery II,Research Associate, 医学部・附属病院, 助手 (20282048)
DOI Hideyuki  Tohoku Univ.Sch.Med.Surgery II,Lecturer, 医学部・附属病院, 講師 (90188839)
SAYAMA Junzo  Tohoku Univ.Sch.Med.Surgery II,Research Associate, 医学部・附属病院, 助手 (60292322)
MIYAZAKI Syukichi  Tohoku Univ.Sch.Med.Surgery II, Research Associate, 医学部, 助手 (50282075)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsstress / cytokine / steroid / IL-6 / カテコールアミン / IL-8 / G-CSF / マクロファージ / ストレスホルモン / Meeylprednisolone
Research Abstract

The purpose of this study is to evaluate and modulate the excessive responses by surgical stress clinically and experimentally.
Excessive production of stress hormones and cytokines were demonstrated after surgical stress, and polyrnorphonu clear cells and macrophages were primedin not only local lesions but also distant tissues, then formation of third space was occurred, which demonstrated by auto radiograph.
In clinically, preoperative administration of small amount of steroids reduced the excessive production of stress hormones and cytokines , and metabollc and clinical course was improved.
In rat and mouse models , production of cytokines( IL-6) were most reduced by 1 hr preoperative administration of methylprednisolone (1mg/ mouse ). There are optimal time ( 1 hr before stress) and optimal doses ( 1mg / mouse).
Macrophage is a great important role in this reaction , because depletion of macrophage made less responses of cytokines as like as administration of steroids.
Further investigations are necessary to elucidate the mechanism of surgicalstress and modulation of its responses.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 大江 大: "ラット下肢虚血再潅流モデルにおける非機能的細胞外液形成の解析" 外科と代謝・栄養. 32(2). 51-59 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 標葉 隆三郎: "steroidによるSIRSの制御" 集中治療. 10(8). 849-854 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Dai OHE,et al.: "An Analysis of Non-Functional Extracellular Fluid Space in the Ischemia-Reperfusion Imjury Model." The Japanese Journal of SURGICAL METABOLISM and NUTRITION. 32 (2). 51-59 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] R.Shineha: "Control of SIRS in Steroid" Intensive & Critical Care Medicine. 10 (8). 849-854 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1997-04-01   Modified: 2016-04-21  

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