Immunoguided Surgery Using Monoclonal Antibody A7 Coupled to Magnetic Particles
| Project/Area Number |
09671329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OTSUJI Eigo Kyoto Prefectural University of Medicine, School of Medicine, Department of Surgery, Assistant Professor, 医学部, 助手 (20244600)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kazuma Kyoto Prefectural University of Medicine, School of Medicine, Department of Surg, 医学部, 助手 (20285258)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | MONOCLONAL / ANTIBODY / A7 / PANCREATIC CANCER / 手術 / リンパ節転移 |
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| Research Abstract |
We examined the retaining in vitro immunoreactivity of ferromagnetic particles bound to Mab A7 and their in vivo distribution in nude mice bearing human pancreatic carcinoma xenografts were examined. A7-Lignosite FML retained binding activities nearly identical to Mab A7. Significantly more of the radiolabeled A7-Lignosite FML accumulated in the tumor than did normal mouse IgG-Lignosite FML (P<0.05). A7-Lignosite FML and ^<125>I labeled normal mouse IgG-Lignosite FML disappeared from blood rapidly. As for all resected normal tissues, the accumulation levels of ^<125>I labeled A7-Lignosite FML were lower than those for the tumors and decreased linearly with time.
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Report
(3 results)
Research Products
(11 results)
