| Project/Area Number |
09671334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | KITASATO UNIVERSITYH |
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Principal Investigator |
YOSHIDA Muneki Kitasato Univ. School of Medicine, Assistant Professor, 医学部, 講師 (50201017)
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| Co-Investigator(Kenkyū-buntansha) |
FURUTA Kazunori Kitasato Univ. School of Medicine, Assistant Professor, 医学部, 講師 (40209177)
TAKAHASHI Tsuyoshi Kitasato Univ. School of Medicine, Assistant Professor, 医学部, 講師 (70245405)
KAKITA Akira Kitasato Univ. School of Medicine, Professor, 医学部, 教授 (90109439)
IINO Zen-ichiro Kitasato Univ. School of Medicine, Research Associate, 医学部, 助手 (90222827)
IZUMIKA Hisanao Kitasato Univ. School of Medicine, Research Associate, 医学部, 助手 (30193379)
北村 雅也 北里大学, 医学部, 助手 (60281325)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | Simulataeus resection of the liver and the pancreas / Liver regeneration / hepatectomy / TGF-α / PCNA-positive cells / Hyaluronic acid / α1-antitrypsin / Acute Phase Proteins / 肝膵臓器相関 / 膵ホルモン / 手術侵襲 / 進行胆のう癌 / HPD / 肝再発 / 耐術能 / 肝不全 / サイトカイン |
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| Research Abstract |
In this study, we performed hepatectomy and pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. Group I Wister rats underwent 70% hepatectomy and group 2 rats underwent 70% hepatectomy plus 50% pancreatectomy. The time course assessment of liver regeneration rates obtained by Fishback's formula demonstrated a difference in rates between the two groups as early as day 3 or day 7 after surgery. Since levels of both PCNA-positive cells and serum TGF- α were significantly higher in the hepatectomy only group, we could prove the difference of liver regeneration between the two groups.
We have concluded that pancreatectomy retards the liver regeneration initiation processes occurring from 24 hrs to 3 days after evisceration. Glucagon/insulin molar ratios most significantly differed between the two groups 3 days after evisceration in the present study. This result was due to increased glucagon level of group 2 at day 3 after evisceration. Our findings suggest that 50'% partial pancreatectomy inhibits the rate of hepatic regeneration, thereby altering the supply of pancreatic hormones, especially glucagon.
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