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ANGIOGENESIS AND MONOCLONAL ANTIBODY UPTAKE IN MICROMETASTASES OF THE LIVER

Research Project

Project/Area Number 09671337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTHE JIKEI UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

YOSHIDA Kazuhiko  THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,LECTURER, 外科学講座・第1, 講師 (90191577)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Kazumi  THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,STAFFS, 外科学講座・第1, 助手 (50287306)
MISAWA Takeyuki  THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,STAFFS, 外科学講座・第1, 助手 (50260956)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Keywordsmonoclonal antibody / colon cancer / liver metastasis
Research Abstract

To determine the relationship between angiogenesis and monoclonal antibody (mAb) uptake in micrometastases, we made a model of hepatic micrometastases after splenic injection of human colon cancer cell (HT-29) in nude mice, and analyze the angiogenesis and mAb (H-15) uptake in the model. In micrometastases which size were between 300*600 mum, a plenty of angiogenesis was found and high accumulation of mAb was identified around newer vessels. This information is very useful to conduct clinical trials of radioimmunotherapy in adjuvant setting.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

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