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Study of the extrahepatic biliary carcinogenesis in the hamsters given cholecystoduodenosotomy with dissection of the common duct

Research Project

Project/Area Number 09671347
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKAWASAKI MEDICAL SCHOOL

Principal Investigator

YAMAMOTO Yasuhisa  Surgery, Kawasaki Medical School, Associate Professor, 医学部, 助教授 (10122459)

Co-Investigator(Kenkyū-buntansha) KIMOTO Masatoshi  Surgery, Kawasaki Medical School, Associate Professor, 医学部, 助教授 (50153226)
TSUNODA Tsukasa  Surgery, Kawasaki Medical School, Professor, 医学部, 教授 (00110841)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsmaljunction / hamster / K-ras / p53 / PCNA labeling index / bile duct carcinoma / BOP / gallbladder carcinoma / PCNA / 胆嚢上皮過形成 / 胆管上皮過形成 / 肝外胆管癌 / K-ras遺伝子 / p53遺伝子 / 膵管癌 / 胆嚢・十二指腸吻合
Research Abstract

An experimental model for the induction of extrahepatic biliary duct carcinomas in hamsters given cholecystoduodenostomy with dissection of the extrahepatic duct at the distal end of the common duct (CDDB) followed by N-nitrosobis(2-oxopropyl)amine (BOP) has been reported. The CDDB procedure greatly accelerates cell turnover in the biliary epithelium. In the present experiment, mutations of K-ras and p53 genes in the induced lesions were investigated by the RT-PCR-SSCP method followed by direct sequencing. Mutations of K-ras, involving a G to A transition in second position of codon 12 of K-ras exon 1, were detected in 6 out of 8 (75%) extrahepatic bile duct carcinomas and 6 out of 11 (54.5%) pancreatic duct carcinomas. However, no mutations of p53 were observed in either tumor type. The results indicate an association between anomalous pancreaticobiliary junction and development of biliary carcinomas that may be pertinent to the human situation, and indicate that condition of the mode … More l predispose to mutations occurring in K-ras but not p53.
Then we followed the hamsters given CDDB procedure without BOP, and evaluated the biliary carcinogenesis of this model. A total of 20 female 7 weeks old Syrian golden hamsters were given CDDB procedure. All hamsters were fed a basal diet and provided drinking water ad libitum without any carcinogen until sacrifice. 6 hamsters were sacrificed 6 month after CDDB, and hyperplasia of the gallbladder epithelium was observed in all of them. PCNA labeling indices of the gallbladder were 8.4±2.2% in normal hamsters, but were 56.2±11.4% in hamsters given CDDB procedure. 14 hamsters were sacrificed 1 year after the surgery, and hyperplasia of the gallbladder epithelium was also observed in all of them. Extrahepatic bile duct carcinoma was observed in one out of 14 -hamsters. Histologically, moderately differentiated adenocarcinoma cells were observed proliferating in the lumen of bile ducts and invading to extra-bile duct tissue. The CDDB procedure greatly accelerates cell turnover in the extrahepatic biliary system. We can observe the extrahepatic biliary carcinogenesis in this model without Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (102 results)

All Other

All Publications (102 results)

  • [Publications] 岩本末治: "膵嚢胞の手術"外科治療. 76・5. 837-840 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鴨井隆一: "胃・十二指腸に早期癌を認めた家族性大腸腺腫症の1例"胃と腸. 32・4. 631-640 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 三宅一郎: "無症状で発見された粘液産生胆癌の1例"臨床と研究. 74・12. 3085-3088 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "5-fluorouracil/cisplatin (FP)療法が無効でMethotrexate/5-fluorouracil交代療法が奏効した進行胃癌の1例"癌と化学療法. 24・13. 2005-2009 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kenji Ohmoto: "Solitary cystic dilatation of the intrahepatic bile duct"J.Clin. Pathol.. 50・7. 617-618 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshimits Majima: "Mutations of K-ras but not p53 genes in billiary duct and paracreatic duct carcinomas induced in hamster by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis (2-oxopropyl) amine"Cancer Letters. 118. 47-53 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "高齢者の周術期ケア.高齢者消化器外科における手術適応;術式の選択"消化器外科Nursing. 2・1. 66-70 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 伊木勝道: "孤立性小腸転移を来した黒色腫の1例"日臨外医会誌. 58・2. 415-418 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水道生: "膵粘液性嚢胞腫瘍の臨床病理学的特徴"病理と臨床. 15・7. 611-618 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "実質臓器切離断端処理の工夫(ドレナージを含めて)"手術. 51・12. 2009-2028 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山本康久: "縫合・吻合法のバイブル、部位(術式)別の縫合・吻合法、ハルトマン術式の肛門側縫合閉鎖"臨床外科. 53・11増. 281-283 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tsukasa Tsunoda: "Topics, Staging and treatment for patients with pancreatic cancer. How small is an early pancreatic cancer?"J.Hep. Bil.Panc.Surg.. 5・2. 128-132 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "肝内結石症に合併する胆管癌;最新の知見"消化器外科. 21・9. 1493-1499 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "術式からみた術前検査、インフォムド・コンセント、術後管理、インスリノーマ手術"消化器外科. 21・5増刊. 819-821 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "胆嚢管原発早期癌の1例"胆道. 12・5. 427-431 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 伊木勝道: "血液透析患者に発生した腹直筋血腫の1例"川崎医学会誌. 24・2. 113-118 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小沼英史: "後腹膜粘液嚢胞腺腫の1例-腹膜外到達経路による摘出術-"手術. 52・6. 889-893 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 久保添忠彦: "大腸癌早期(術後1年未満)死亡症例の検討"日本外科系連合学会雑誌. 23・4. 670-673 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "進行胃癌に対するMTX/5-FU交代療法の効果とその問題点"癌と化学療法. 25・4. 541-546 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山本晋一郎: "エタノールおよび酢酸注入療法が奏効した大腸癌肝転移切除後再発の2例"癌と化学療法. 25・5. 751-755 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 金澤成雄: "各保存液における分離膵ランゲルハンス島のcell viabilityに関する検討"移植. 33・2. 73-81 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sueharu Iwamoto: "Inflammatory pseudotumor of the liver : A case report"Kawasaki Med.J.. 24・2. 79-84 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katsumichi Iki: "Increased telomerase activity in intrahepatic cholangiocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in hamsters"Cancer Letters. 131. 185-190 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshimitsu Majima: "Inhibitory effects of β-carotene, palm carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters"Pancreas. 16・1. 13-18 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hideo Ozaki: "The prognostic significance of lymph node metastasis and intrapancreatic perineural invation in pancreatic cancer after curative resection"Surg.Tody Jpn.J.Surg. 29. 16-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuwako Komaki: "MRI-histological correlation of abdominal and intra-abdominal desmoid tumors"Kawasaki Med.J.. 25・1. 15-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuru Mizuno: "Solitary metastatic malignant melanoma of the small intestine : Findings obtained during intraoperative enteroscopy"Dig.Endosc.. 11・1. 47-51 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Kanazawa: "Malignant mesothelioma of the tunica vaginalis testis : Report of a case"Surg.Today Jpn.J.Surg.. 29. 1106-1110 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Kanazawa: "A marker to assess islet cell viability following cold storage in different solutions and to predict islet cell function following"Cell Transplantation. 8. 383-388 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takayuki Asakawa: "Case report. Primary hepatic carcinoid tumor"J.Gastroenterol. 34. 123-127 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katsumichi Iki: "Expression of matrix metalloproteinase 2 (MMR-2), membrane type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis (2-oxopropyl) amine"Carcinogenesis. 20・7. 1323-1329 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小牧久和子: "画像診断ライブラリー.腹腔、腹壁のデモイド腫瘍のMRIと組織像の対比"日本医事新報. 3923. 69-72 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "膵胆管合流異常症と胆道癌"保健福祉総合施設誌. 5・1. 11-19 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "(6)膵外分泌機能検査"消化器外科NURSING. 4・増刊. 184-193 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 都築昌之: "症例.CT上Mercedes Benz signを呈した胆嚢結石症の1例"内科. 84・4. 784-785 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 金澤成雄: "周辺機器合併切除により摘出した後腹膜巨大平滑筋肉腫の2例"日臨外会誌. 60・10. 2765-2770 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 川島邦裕: "80歳以上超高齢者大腸癌手術症例の検討"川崎医会誌. 25・3. 165-172 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 垂水研一: "画像上癌と考えられたが生検陰性であった進行胃癌の1例"胃と腸. 34・12. 1541-1547 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "胆道癌・膵癌の手術と看護"OPE nursing. 14・2. 46-50 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 金澤成雄: "直腸・肛門部に発生した悪性黒色腫の2例"日臨外会誌. 60・11. 2986-2990 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山下和城: "盲嚢および短絡が混在したbind pouch syndromeの1例"日臨外会誌. 60・12. 3202-3205 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小堀陽一郎: "Multiple lymphomatous polyposisを呈した空腸follicle center lymphomaの1例"日消誌. 97・1. 48-53 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "新外科学大系、追補2.肝・胆・膵の外科、外科と分子生物学"中山書店. 9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "専門医のための消化器外科学レビュー'97-最新主要文献と解説-"総合医学社. 5 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tsukasa Tsunoda: "Surgical Diseases of the Pancreas. Third Edition"Williams & Wilkins. 10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tsukasa Tsunoda: "The Pancreas-A Clinical Textbook"Blackwell Scientific Publications. 7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "専門医のための消化器外科学レビュー'98-最新主要文献と解説-"総合医学社. 6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "消化器外科事典、膵臓の手術"メディカ出版. 2 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩本末治: "消化器外科事典、膵臓の手術"メディカ出版. 3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 角田司: "専門医のための消化器外科学レビュー'99-最新主要文献と解説-"総合医学社. 6 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kenji Ohmoto, et al: "Solitary cystic dilatation of the intrahepatic bile duct"J.Clin.Pathol.. 50(7). 617-618 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshimitsu Majima, et al: "Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinomas induced in hamster by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis (2-oxopropyl) amine"Cancer Letters. 118. 47-53 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tsukasa Tsunoda, et al: "Topics. Staging and treatment for patients with pancreatic cancer. How small is an early pancreatic cancer?"J.Hep.Bil.Panc.Surg.. 5(2). 128-132 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suharu Iwamoto, et al: "Inflammatory pseudotumor of the liver : A case report"Kawasaki Med.J.. 24(2). 79-84 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katsumichi Iki, et al: "Increased telomerase acitivity in intrahepatic cholangiocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in hamsters"Cancer Letters. 131. 185-190 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshimitsu Majima, et al: "Inhibitory effects of β-carotene, palm carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters"Pancreas. 16(1). 13-18 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hideo Ozaki, et al: "The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection"Surg.Today Jpn.J.Surg.. 29. 16-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuwako Komaki, et al: "MRI-histological correlation of abdominal and intra-abdominal desmoid tumors"Kawasaki Med.J.. 25(1). 15-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuru Mizuno, et al: "Solitary metastatic malignant melanoma of the small intestine: Findings obtained during intraoperative enteroscopy"Dig.Endosc.. 11(1). 45-51 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Kanazawa, et al: "Malignant mesothelioma of the tunica vaginalis testis : Report of a case"Surg.Today Jpn.J.Surg.. 29. 1106-1110 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Kanazawa, et al: "A marker to assess islet cell viability following cold storage in different solutions ana to predict islet cell function following transplantation"Cell Transplantation. 8. 383-388 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takayuki Asakawa, et al: "Case report. Primary hepatic carcinoid tumor"J.Gastroenterol.. 34. 123-127 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katsumichi Iki, et al: "Expression of matrix metalloproteinase 2 (MMP-2), membrane type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis (2-oxopropyl) amine"Carcinogenesis. 20(7). 1323-1329 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hideo Ozaki: "The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection"Surg.Today Jpn.J.Surg. 29. 16-22 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kuwako Komaki: "MRI-histological correlation of abdominal and intra-abdominal desmoid tumors"Kawasaki Med.J.. 25・1. 15-22 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mitsuru Mizuno: "Solitary metastatic malignant melanoma of the small intestine : Findings obtained during intraoperative enteroscopy"Dig.Endosc.. 11・1. 47-51 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shigeo Kanazawa: "Malignant mesothelioma of the tunica vaginalis testis : Report of a case"Surg.Today Jpn.J.Surg. 29. 1106-1110 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shigeo Kanazawa: "A marker to assess islet cell viability following cold strage in different solutions and to predict islet cell function following transplantation"Cell Transplantation. 8. 383-388 (1999)

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  • [Publications] Takayuki Asakawa: "Case report.Primary hepatic carcinoid tumor"J.Gastroenterol. 34. 123-127 (1999)

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  • [Publications] Katsumichi Iki: "Expression of matrix metalloproteinase 2(MMP-2),membrane type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyal)amine"Carcinogenesis. 20・7. 1323-1329 (1999)

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  • [Publications] 小牧 久和子: "画像診断ライブラリー.腹腔、腹壁のデスモイド腫瘍のMRIと組織像の対比"日本医事新報. 3923. 69-72 (1999)

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  • [Publications] 角田 司: "膵胆管合流異常症と胆道癌"保健福祉総合施設誌. 5・1. 11-19 (1999)

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  • [Publications] 岩本 末治: "(6)膵外分泌機能検査"消火器外科NURSING. 4・増刊. 184-193 (1999)

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  • [Publications] 都築 昌之: "症例.CT上Mercedes Bens signを呈した胆嚢結石症の1例"内科. 84・4. 784-785 (1999)

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  • [Publications] 金澤 成雄: "周辺臓器合併切除により摘出した後腹膜巨大平滑筋肉腫の2例"日臨外会誌. 60・10. 2765-2770 (1999)

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  • [Publications] 川島 邦裕: "80歳以上超高齢者大腸癌手術症例の検討"川崎医会誌. 25・3. 165-172 (1999)

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  • [Publications] 垂水 研一: "画像上癌と考えられたが生検陰性であった進行胃癌の1例"胃と腸. 34・12. 1541-1547 (1999)

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  • [Publications] 岩本 末治: "胆道癌・膵癌の手術と看護"OPE nursing. 14・12. 46-50 (1999)

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  • [Publications] 金澤 成雄: "直腸・肛門部に発生した悪性黒色腫の2例"日臨外会誌. 60・11. 2986-2990 (1999)

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  • [Publications] 山下 和城: "盲嚢および短絡が混在したblind pouch syndromeの1例"日臨外会誌. 60・12. 3202-3205 (1999)

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  • [Publications] 小堀 陽一郎: "Multiple lymphomatous polyposisを呈した空腸follicle center lymphomaの1例"日消誌. 97・1. 48-53 (2000)

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  • [Publications] 岩本 末治: "消化器外科辞典、膵臓の手術"メディカ出版. 2 (1999)

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  • [Publications] 岩本 末治: "消化器外科辞典、膵臓の手術"メディカ出版. 3 (1999)

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  • [Publications] 角田 司: "専門医のための消化器外科科学レビュー'99-最新主要文献と解説-"総合医学社. 6 (1999)

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  • [Publications] 岩元 末治 他: "進行胃癌に対するMTX/5-Fu交代療法の効果とその問題点" 癌と化学療法. 25・4. 541-546 (1998)

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  • [Publications] 山本晋一郎 他: "エタノールおよび酢酸注入療法が奏効した大腸癌肝転移切除後再発の2例" 癌と化学療法. 25・5. 751-755 (1998)

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  • [Publications] 久保添忠彦 他: "大腸癌早期(術後1年未満)死亡症例の検討" 日本外科系連合学会雑誌. 23・4. 670-673 (1998)

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  • [Publications] Tsunoda Tsukasa,et al.: "Staging and treatment for patients with pancreatic cancer.How small is an early pancreatic cancer?" J.Hep.Bil.Pancr.Surg.5・2. 128-132 (1998)

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  • [Publications] 角田 司 他: "肝内結石症に合併する胆管癌;最新の知見" 消化器外科. 21・9. 1493-1499 (1998)

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  • [Publications] Iki Katsumichi,et al.: "Increased telomerase activity in intrahepatic cholangiocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters" Cancer Lett.131. 185-190 (1998)

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  • [Publications] Ozaki Hideo,et al.: "The prognostic significance of lymph node metastasis and intrapancreatic perineural in vasion in pancreatic cancer after curative resection" Surg.-Today Jpn.J.Surg.29. 16-22 (1999)

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  • [Publications] 角田 司 他: "専門医のための消化器外科学レビュー'99-最新主要文献と解説" 総合医学社(東京), 6 (1999)

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  • [Publications] Tsunoda Tsukasa,et al.: "The Pancreas-A Clinical Textbook" Blackwell Scientific Publications (London), 7 (1998)

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  • [Publications] 岩本末治: "高齢者の周術期ケア.高齢者消化器外科における手術適応;術式の選択" 消化器外科Nursing. 2・1. 66-70 (1997)

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  • [Publications] 伊木勝道: "孤立性小腸転移を来した黒色種の1例" 日臨外医会誌. 58・2. 415-418 (1997)

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  • [Publications] 岩本末治: "膵嚢胞の手術" 外科治療. 76・5. 837-840 (1997)

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  • [Publications] 岩本末治: "5-fluorouracil/cisplatin (FP)療法が無効でMethotrexate/5-fluorouracil交代療法が奏効した進行胃癌の1例" 癌と化学療法. 24・13. 2005-2009 (1997)

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  • [Publications] Toshimitsu Majima: "Mutations of K-ras but not P53 genes in biliary duct and pancreatic duct carcinomas induced in hamster by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis (2-oxopropyl) amine" Cancer Letters. 118. 47-53 (1997)

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  • [Publications] Toshimitsu Majima: "Inhibitory effects of β-carotene, plam carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters." Pancreas. 16・1. 13-18 (1998)

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  • [Publications] 角田 司: "専門医のための消化器外科学レビュー'97-最新主要文献と解説" 総合医学社,東京, 5 (1997)

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  • [Publications] 角田 司: "新外科学大系、追補2 肝・胆・膵の外科、外科と分子生物学" 中山書店,東京, 13 (1997)

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  • [Publications] Tsukasa Tsunoda: "Surgical Diseases of the Pancreas" Williams & Wilkins, Baltimore, Philadelphia, London, Paris, Bangkok, Buenos Aires, Hong Kong Munich, Sydney, Tokyo, Wroclaw, 10 (1998)

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Published: 1997-04-01   Modified: 2016-04-21  

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